New combo therapy aims to wipe out prostate tumors before surgery

NCT ID NCT06834321

Recruiting now Disease control Sponsor: baotai Liang Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This Phase 2 trial tests whether adding homoharringtonine, a drug from a plant, to standard hormone therapy can better shrink or eliminate prostate cancer before surgery. About 96 men with locally advanced or limited spread prostate cancer will receive either the drug combo or a placebo plus hormones. The main goal is to see if the tumor completely disappears or becomes very small in the removed prostate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Homoharringtonine (a plant-derived drug) combined with androgen deprivation therapy (hormone therapy)
What this could lead to: If it works, this could lead to a more effective pre-surgery treatment that reduces or eliminates prostate tumors, potentially improving long-term outcomes.
What could go wrong: This is an early Phase 2 trial with only 96 participants, so results may not apply broadly. The drug can cause side effects like bone marrow suppression, and the combination may not prove better than standard therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CA

Contacts and locations

Locations

The First People Hospital of Nantong City
RECRUITING

Nantong, Jiangsu, China
Zhongda Hospital
RECRUITING

Nanjing, Jiangsu, China

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