Drug interaction study reveals how itraconazole and rifampin alter HMPL-453 levels
NCT ID NCT07697157
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study investigates how two common drugs—itraconazole (a CYP3A and P-gp inhibitor) and rifampin (a CYP enzyme inducer)—affect the levels of HMPL-453 in the blood of healthy adults. Forty participants will take HMPL-453 alone and then with each of these drugs to see how they change drug exposure and safety. The goal is to guide future dosing recommendations for patients who may need HMPL-453 alongside other medications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HMPL-453 tartrate tablets
- What this could lead to
- If successful, this study could help determine safe and effective dosing of HMPL-453 when taken with common drugs that affect liver enzymes.
- What could go wrong
- This is an early-phase study in healthy volunteers, not patients. The results may not predict effects in people with the target disease, and drug interactions could increase side effects or reduce effectiveness.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
yijishan Hospital
Wuhu, Anhui, 241000, China
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