Immune cell boost after transplant shows promise against HIV and lymphoma

NCT ID NCT04975698

First seen Nov 01, 2025 · Last updated Apr 24, 2026 · Updated 29 times

Summary

This study tested whether giving HIV-specific immune cells (called HST-NEETs) after a high-dose chemotherapy and stem cell transplant is safe and effective for people with HIV-related lymphoma. Twelve participants received the treatment. The goal was to see if the cells could reduce the amount of hidden HIV in the body. The study focused on feasibility and early signs of controlling the virus, not a cure.

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Contacts and locations

Locations

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • City of Hope National Medical Center

    Duarte, California, 91010, United States

  • Georgetown

    Washington D.C., District of Columbia, 20057, United States

  • H. Lee Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21231, United States

  • MD Anderson

    Houston, Texas, 77030, United States

  • Memorial Sloan Kettering (MSKCC)

    New York, New York, 10065, United States

  • Northside

    Atlanta, Georgia, 30342, United States

  • University of Illinois

    Chicago, Illinois, 60612, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

Conditions

Explore the condition pages connected to this study.