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High-Protein diet may trigger cellular stress signals, small study hints

NCT ID NCT06621901

Knowledge-focused Sponsor: TC Erciyes University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study investigates whether eating a high-protein diet for 10 days changes levels of endoplasmic reticulum stress markers in the blood. Twenty healthy adults aged 19–45 with a normal BMI will follow a high-protein diet (about 30% of calories from protein) and later a normal-protein diet as a control. Researchers will measure stress-related proteins such as GRP78, PERK, Nrf2, and GPx-1 to better understand the short-term cellular effects of high protein intake.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high protein diet (30% of total energy from protein) for 10 days, compared with a normal protein diet for 10 days
What this could lead to
If this trial yields clear results, it could help explain how high protein diets affect cellular stress and guide safer dietary recommendations.
What could go wrong
This is a small, short-term study in healthy people, so findings may not apply to the general population or to long-term use. The measured stress markers may not translate to meaningful health outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Sep 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Being between 19-45 years of age, * Not changing physical activity throughout the study, * Having a BMI of 18.5-24.9 kg/m2, * Being healthy Exclusion Criteria: * Having a BMI of \<18.5 and ≥25 kg/m2, * Having a chronic disease, * Smoking and drinking alcohol, * Using vitamin-mineral supplements and herbal supplements, * Being pregnant or breastfeeding, * Having entered menopause, * Being on any diet.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Effect of high protein diet on endoplasmic reticulum stress

Contacts and locations

Locations

  • Erciyes University

    Kayseri, Turkey (Türkiye)