New experimental pill takes on tough cancers
NCT ID NCT04390737
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests an experimental drug called HH2853 in people with certain types of blood cancer (non-Hodgkin lymphoma) or advanced solid tumors that have come back or stopped responding to treatment. The drug is taken as a tablet twice a day. The main goals are to find the safest dose and to see if the drug can shrink tumors. About 254 adults will take part across multiple hospitals.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HH2853 (an experimental drug taken as a tablet)
- What this could lead to
- If it works, this could point toward a new treatment option for people with certain blood cancers or advanced solid tumors that have not responded to other therapies.
- What could go wrong
- This is an early, first-in-human study, so the drug may not work or may cause unexpected side effects. The trial is small and focused on finding the right dose, not proving a cure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Affiliated Drum Tower Hospital, Medical School of Nanjing University
RECRUITINGNanjing, Jiangsu, China
Contact Email: •••••@•••••
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Affiliated Tumor Hospital of Guangxi Medical University
RECRUITINGNanning, Guangxi, China
Contact Email: •••••@•••••
Contact
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Beijing Cancer Hospital
RECRUITINGBeijing, Beijing Municipality, 100142, China
Contact Email: •••••@•••••
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Beijing Cancer Hospital
RECRUITINGBeijing, Beijing Municipality, China
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Beijing Cancer Hospital
RECRUITINGBeijing, China
Contact Email: •••••@•••••
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Beijing Jishuitan Hospital
RECRUITINGBeijing, Beijing Municipality, China
Contact Email: •••••@•••••
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Henan Cancer Hospital
RECRUITINGZhengzhou, Henan, China
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Hunan Cancer Hospital
RECRUITINGChangsha, Hunan, China
Contact Email: •••••@•••••
Contact
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Liaoning Cancer Hospital&Institute
RECRUITINGShenyang, Liaoning, China
Contact Email: •••••@•••••
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Linyi Tumor Hospital
RECRUITINGLinyi, Shandong, China
Contact Email: •••••@•••••
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Mayo Clinic
COMPLETEDPhoenix, Arizona, 85054, United States
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Mayo Clinic
COMPLETEDJacksonville, Florida, 32224, United States
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Mayo Clinic
COMPLETEDRochester, Minnesota, 55905, United States
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NEXT Oncology
COMPLETEDSan Antonio, Texas, 78240, United States
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Shanghai Sixth People's Hospital
RECRUITINGShanghai, Shanghai Municipality, China
Contact Email: •••••@•••••
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Shanxi Cancer Hospital
RECRUITINGTaiyuan, Shanxi, China
Contact Email: •••••@•••••
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Shengjing Hospital Of China Medical University
RECRUITINGShenyang, Liaoning, China
Contact Email: •••••@•••••
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Sun Yat-Sen University Cancer Hospital
RECRUITINGGuangzhou, Guangdong, China
Contact
Contact Email: •••••@•••••
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Sun Yat-Sen University Cancer Hospital
RECRUITINGGuangzhou, China
Contact Email: •••••@•••••
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The First Affiliated Hospital of Anhui Medical University
RECRUITINGHefei, Anhui, China
Contact Email: •••••@•••••
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Tianjin Cancer Hospital
RECRUITINGTianjin, Tianjin Municipality, China
Contact
Contact Email: •••••@•••••
Contact
Contact
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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITINGWuhan, Hubei, China
Contact
Contact Email: •••••@•••••
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West China Hospital of Sichuan University
RECRUITINGChengdu, Sichuan, China
Contact Email: •••••@•••••
Contact
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Zhejiang Cancer Hospital
RECRUITINGHangzhou, Zhejiang, China
Contact
Contact Email: •••••@•••••
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Zhongshan Hospital Fudan University
RECRUITINGShanghai, Shanghai Municipality, China
Contact Email: •••••@•••••
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Other studies related to the condition(s) this trial covers.
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- Can a new Liposome-Wrapped drug shrink Hard-to-Treat solid tumors?
- Can a new antibody help the immune system fight advanced cancers?
- Can a cancer drug reboot the immune system after a stem cell transplant?
- Can an experimental pill slow advanced solid tumors? a phase 1 trial puts HW221043 to the test.