New drug duo fights Tough-to-Treat breast cancer

NCT ID NCT04539938

Completed Disease control Sponsor: Seagen, a wholly owned subsidiary of Pfizer Source: ClinicalTrials.gov ↗

Summary

This study tested a combination of two targeted drugs, tucatinib and trastuzumab deruxtecan, for people with advanced HER2-positive breast cancer that had spread or could not be removed by surgery. The main goal was to see how well the combination worked to shrink tumors and control the cancer, while also carefully tracking side effects. All 70 participants received both drugs as part of this Phase 2 trial.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

(IRB# 20-001502) Ronald Reagan UCLA Medical Center, Drug Information Center

Los Angeles, California, 90095, United States
Abbott Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Allina Health Cancer Institute

Saint Paul, Minnesota, 55102, United States
Allina Health Cancer institute

Minneapolis, Minnesota, 55407, United States
Arizona Oncology Associates, PC - HOPE

Tucson, Arizona, 85704, United States
Arizona Oncology Associates, PC - HOPE

Tucson, Arizona, 85711, United States
Atlanta Cancer Care - Atlanta

Atlanta, Georgia, 30342, United States
Atlanta Cancer Care - Cumming

Cumming, Georgia, 30041, United States
Atlanta Cancer Care - Stockbridge

Stockbridge, Georgia, 30281, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
City of Hope (City of Hope National Medical Center, City of Hope Medical center)

Duarte, California, 91010, United States
City of Hope Investigational Drug Services (IDS)

Duarte, California, 91010, United States
Dana Farber Cancer Institute- Chestnut Hill

Newton, Massachusetts, 02459, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Emory University Hospital

Atlanta, Georgia, 30322, United States
Evelyn H. Lauder Breast and Imaging Center (BAIC).

New York, New York, 10065, United States
Florida Cancer Specialists

Altamonte Springs, Florida, 32701, United States
Florida Cancer Specialists

Brandon, Florida, 33511, United States
Florida Cancer Specialists

Clearwater, Florida, 33761, United States
Florida Cancer Specialists

Gainesville, Florida, 32605, United States
Florida Cancer Specialists

Largo, Florida, 33770, United States
Florida Cancer Specialists

Lecanto, Florida, 34461, United States
Florida Cancer Specialists

Ocala, Florida, 34474, United States
Florida Cancer Specialists

Orange City, Florida, 32763, United States
Florida Cancer Specialists

Orlando, Florida, 32806, United States
Florida Cancer Specialists

St. Petersburg, Florida, 33705, United States
Florida Cancer Specialists

Tampa, Florida, 33607, United States
Florida Cancer Specialists

Tavares, Florida, 32778, United States
Florida Cancer Specialists

The Villages, Florida, 32159, United States
Florida Cancer Specialists

Trinity, Florida, 34655, United States
Florida Cancer Specialists

Winter Park, Florida, 32789, United States
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Georgetown University Medical Center

Washington D.C., District of Columbia, 20007, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Harry and Jeanette Weinberg Cancer Institute at Franklin Square

Baltimore, Maryland, 21237, United States
MSK Basking Ridge

Basking Ridge, New Jersey, 07920, United States
MSK Bergen

Montvale, New Jersey, 07645, United States
MSK Commack

Commack, New York, 11725, United States
MSK Monmouth

Middletown, New Jersey, 07748, United States
MSK Nassau

Uniondale, New York, 11553, United States
MSK Westchester

Harrison, New York, 10604, United States
Magee-Womens Hospital of UPMC

Pittsburgh, Pennsylvania, 15213, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy

Long Island City, New York, 11101, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital - Unity Campus

Fridley, Minnesota, 55432, United States
Minnesota Oncology Hematology PA

Saint Paul, Minnesota, 55102, United States
Minnesota Oncology Hematology, PA

Coon Rapids, Minnesota, 55433, United States
Minnesota Oncology Hematology, PA

Fridley, Minnesota, 55433, United States
Minnesota Oncology Hematology, PA

Minneapolis, Minnesota, 55404, United States
Minnesota Oncology Hematology, PA

Saint Paul, Minnesota, 55102, United States
NHCI Suburban Hematology-oncology Associates - Duluth

Duluth, Georgia, 30096, United States
NHCI Suburban Hematology-oncology Associates - lawrenceville

Lawrenceville, Georgia, 30046, United States
Northside Hospital, Inc - GCS/Athens

Athens, Georgia, 30606, United States
Northside Hospital, Inc - GCS/Blairsville

Blairsville, Georgia, 30512, United States
Northside Hospital, Inc - GCS/Canton

Canton, Georgia, 30114, United States
Northside Hospital, Inc - GCS/Macon

Macon, Georgia, 31217, United States
Northside Hospital, Inc. - Central Research Department

Atlanta, Georgia, 30342, United States
Northside Hospital, Inc. - GCS/Center Pointe

Atlanta, Georgia, 30342, United States
Northside Hospital, Inc. - GCS/Decatur

Decatur, Georgia, 30033, United States
Northside Hospital, Inc. - GCS/Marietta

Marietta, Georgia, 30060, United States
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care

Blacksburg, Virginia, 24060, United States
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care

Low Moor, Virginia, 24457, United States
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care

Roanoke, Virginia, 24014, United States
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care

Salem, Virginia, 24153, United States
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care

Wytheville, Virginia, 24382, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists

Omaha, Nebraska, 68114, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists

Omaha, Nebraska, 68124, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists

Omaha, Nebraska, 68130, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists

Papillion, Nebraska, 68046, United States
Providence Cancer Institute Franz Clinic

Portland, Oregon, 97213, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Sarah Cannon Research Institute

Chattanooga, Tennessee, 37404, United States
Tennessee Oncology, PLLC

Chattanooga, Tennessee, 37403, United States
Tennessee Oncology, PLLC

Chattanooga, Tennessee, 37404, United States
Tennessee Oncology, PLLC

Cleveland, Tennessee, 37311, United States
Tennessee Oncology, PLLC

Dickson, Tennessee, 37055, United States
Tennessee Oncology, PLLC

Franklin, Tennessee, 37067, United States
Tennessee Oncology, PLLC

Gallatin, Tennessee, 37066, United States
Tennessee Oncology, PLLC

Hendersonville, Tennessee, 37075, United States
Tennessee Oncology, PLLC

Hermitage, Tennessee, 37076, United States
Tennessee Oncology, PLLC

Lebanon, Tennessee, 37909, United States
Tennessee Oncology, PLLC

Murfreesboro, Tennessee, 37129, United States
Tennessee Oncology, PLLC

Nashville, Tennessee, 37203, United States
Tennessee Oncology, PLLC

Nashville, Tennessee, 37205, United States
Tennessee Oncology, PLLC

Nashville, Tennessee, 37207, United States
Tennessee Oncology, PLLC

Nashville, Tennessee, 37211, United States
Tennessee Oncology, PLLC

Shelbyville, Tennessee, 37160, United States
Tennessee Oncology, PLLC

Smyrna, Tennessee, 37167, United States
The Emory Clinic

Atlanta, Georgia, 30322, United States
The Sarah Cannon Research Institute

Nashville, Tennessee, 37203, United States
The University of Texas M.D. Anderson Cancer Center

Houston, Texas, 77030, United States
U.T. MD Anderson Cancer Center

Houston, Texas, 77030, United States
UC Health Lone Tree Medical Center

Lone Tree, Colorado, 80124, United States
UCLA Hematology/Oncology

Los Angeles, California, 90095, United States
UCLA Hematology/Oncology - Alhambra

Alhambra, California, 91801, United States
UCLA Hematology/Oncology - Burbank

Burbank, California, 91505, United States
UCLA Hematology/Oncology - Laguna Hills

Laguna Hills, California, 92653, United States
UCLA Hematology/Oncology - Pasadena

Pasadena, California, 91105, United States
UCLA Hematology/Oncology - San Luis Obispo

San Luis Obispo, California, 93401, United States
UCLA Hematology/Oncology - Santa Barbara

Santa Barbara, California, 93105, United States
UCLA Hematology/Oncology - Santa Monica

Santa Monica, California, 90404, United States
UCLA Hematology/Oncology - Ventura

Ventura, California, 93003, United States
UCLA Hematology/Oncology - Westlake

Westlake Village, California, 91361, United States
UCLA Hematology/Oncology Parkside

Santa Monica, California, 90404, United States
UPMC Cancer Centers William M. Cooper Ambulatory Care Pavilion of the Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
UPMC Hillman Cancer Center Erie

Erie, Pennsylvania, 16505, United States
UPMC Hillman Cancer Center Mountainview

Greensburg, Pennsylvania, 15601, United States
UPMC Hillman Cancer Center Passavant North

Cranberry Township, Pennsylvania, 16066, United States
UPMC Hillman Cancer Center UPMC East

Monroeville, Pennsylvania, 15146, United States
UPMC Hillman Cancer Center UPMC Passavant

Pittsburgh, Pennsylvania, 15237, United States
UPMC Hillman Cancer Center Uniontown

Uniontown, Pennsylvania, 15401, United States
UPMC Hillman Cancer Center Upper Saint Clair

Pittsburgh, Pennsylvania, 15102, United States
UPMC Hillman Cancer Center Washington

Washington, Pennsylvania, 15301, United States
US Oncology Investigational Product Center (IPC)

Irving, Texas, 75063, United States
US Oncology Investigational Products Center (IPC)

Irving, Texas, 75063, United States
US Oncology lnvestigational Products Center (IPC)

Irving, Texas, 75063, United States
UW Health Oncology - One South Park

Madison, Wisconsin, 53715, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
University Of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
University Of Alabama at Birmingham

Birmingham, Alabama, 35249, United States
University of Alabama at Birmingham, IDS Pharmacy

Birmingham, Alabama, 35249, United States
University of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center

San Francisco, California, 94158, United States
University of Colorado Denver CTO/CTRC - Outpatient.

Aurora, Colorado, 80045, United States
University of Colorado Hospital - Anschutz Cancer Pavilion (ACP)

Aurora, Colorado, 80045, United States
University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP)

Aurora, Colorado, 80045, United States
University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP)

Aurora, Colorado, 80045, United States
University of Pittsburgh Cancer Institute Investigational Drug Service UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
University of Wisconsin Clinical Science Center

Madison, Wisconsin, 53792, United States
Virginia Cancer Specialists, PC

Fairfax, Virginia, 22031, United States
Virginia Cancer Specialists, PC

Gainesville, Virginia, 20155, United States
Virginia Cancer Specialists, PC

Leesburg, Virginia, 20176, United States
Virginia Cancer Specialists, PC

Reston, Virginia, 20190, United States
Washington Cancer Institute at MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Winship Cancer Institute / Emory University School of Medicine

Atlanta, Georgia, 30322, United States
Winship Cancer Institute @ Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Zuckerberg San Francisco General Hospital- Breast Clinic

San Francisco, California, 94110, United States
Zuckerberg San Francisco General Hospital- Oncology Clinic

San Francisco, California, 94110, United States

Conditions

Explore the condition pages connected to this study.

HER2-POSITIVE BREAST CANCER