New hope for hard-to-treat lung cancer: drug combo targets HER2 mutations

NCT ID NCT07377916

First seen Feb 01, 2026 · Last updated May 03, 2026 · Updated 11 times

Summary

This study tests a combination of two drugs (SHR-A1811 and pertuzumab) in 60 adults with advanced non-small cell lung cancer that has a specific change called HER2 alteration and has worsened after at least one prior treatment. The goal is to see if the combo can shrink tumors or slow the cancer's growth. Participants will receive the drugs until the cancer progresses or side effects become too severe.

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