New hope for hepatitis c: experimental drug combo shows promise
NCT ID NCT01753557
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 3 trial tested an experimental drug called MP-424, combined with two standard hepatitis C medications (pegylated interferon and ribavirin), in 54 adults with genotype 1 hepatitis C. Participants were either new to treatment or had relapsed after previous therapy. The main goal was to see if the virus stayed undetectable 24 weeks after treatment ended (sustained viral response).
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MP-424 (an experimental antiviral drug) combined with pegylated interferon alfa-2a and ribavirin
What this could lead to
If successful, this combination could offer a new treatment option for people with genotype 1 hepatitis C who have not been treated before or who relapsed after prior therapy.
What could go wrong
This is a small, completed Phase 3 trial with only 54 participants, so results may not apply to everyone. The regimen includes interferon, which can cause significant side effects like flu-like symptoms and depression.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Toranomon Hospital
Kawasaki, Takatsu-ku, 213-8587, Japan