Plugging the leak: new device aims to fix faulty heart valves without major surgery
NCT ID NCT04489823
First seen Feb 14, 2026 · Last updated Apr 17, 2026 · Updated 7 times
Summary
This study is testing a small plug device to seal leaks that can develop around surgically replaced heart valves. The device is delivered through a catheter to avoid another major open-heart surgery. Researchers aim to see if this procedure is safe and effective at reducing the leak and improving symptoms like heart failure and anemia in 200 adults.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Baptist Memorial Hospital
Memphis, Tennessee, 38120, United States
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Carilion Roanoke Memorial Hospital
Roanoke, Virginia, 24014, United States
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Edinburgh Heart Centre
Edinburgh, Lothian, EH16 4SA, United Kingdom
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Emory University Hospital
Atlanta, Georgia, 30322, United States
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Gornoslaskie Centrum Medyczne im.prof. Leszka Gieca
Katowice, Silesian Voivodeship, 40-635, Poland
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Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Hospital Ramón y Cajal
Madrid, Madrid, 28034, Spain
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Hospital Universitario de Salamanca
Salamanca, Spain
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Institut de Cardiologie de Montreal (Montreal Heart Inst.)
Montreal, Quebec, H1T 1C8, Canada
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Institut de Cardiologie de Quebec (Hôpital Laval)
Québec, Quebec, G1V 4G5, Canada
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Intermountain Medical Center
Murray, Utah, 84157, United States
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Lenox Hill Hospital
New York, New York, 10021, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Minneapolis Heart Institute
Minneapolis, Minnesota, 55407, United States
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New York Presbyterian Hospital/Cornell University
New York, New York, 10021, United States
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Ospedale San Raffaele
Milan, Lombard, 20132, Italy
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Papworth Hospital NHS Foundation Trust
Cambridge, United Kingdom
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Providence Sacred Heart Medical Center
Spokane, Washington, 99202, United States
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Saint Luke's Hospital of Kansas City
Kansas City, Missouri, 64111, United States
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St. Antonius Ziekenhuis
Nieuwegein, Utrecht, 3435 CM, Netherlands
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The Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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The Royal Sussex County Hospital
Brighton, Soeast, BN25BE, United Kingdom
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University Hospital - Univ. of Alabama at Birmingham (UAB)
Birmingham, Alabama, 35249, United States
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University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States
Conditions
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