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Major heart disease trial aims to slash deaths and hospital stays

NCT ID NCT07052903

Recruiting now Disease control Sponsor: Alnylam Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether an investigational drug called nucresiran can help people with a serious heart condition called ATTR amyloidosis cardiomyopathy. The main goal is to see if the drug reduces the risk of death and the need for urgent heart-related hospital visits compared to a placebo. About 1,250 participants worldwide will receive either the drug or a placebo injection to compare outcomes.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

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    La Jolla, California, 92037, United States

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    Washington D.C., District of Columbia, 20010, United States

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    Brandon, Florida, 33511, United States

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    Atlanta, Georgia, 30309, United States

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    Gainesville, Georgia, 30501, United States

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    Tucker, Georgia, 30084, United States

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    Indianapolis, Indiana, 46202, United States

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    Indianapolis, Indiana, 46260, United States

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    Kansas City, Kansas, 66160, United States

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    Boston, Massachusetts, 02118, United States

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    Detroit, Michigan, 48202, United States

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    Rochester, Minnesota, 55905, United States

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    St Louis, Missouri, 63110, United States

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    Manhasset, New York, 11030, United States

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    New York, New York, 10065, United States

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    The Bronx, New York, 10467, United States

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    Charlotte, North Carolina, 28204, United States

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    Lancaster, Pennsylvania, 17602, United States

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    Philadelphia, Pennsylvania, 19104, United States

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    Dallas, Texas, 75246, United States

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    Houston, Texas, 77030, United States

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    Salt Lake City, Utah, 84132, United States

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    Charlottesville, Virginia, 22903, United States

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    Norfolk, Virginia, 23507, United States

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    Spokane, Washington, 99204, United States

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    Buenos Aires, C1025ABI, Argentina

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    Buenos Aires, C1093AAS, Argentina

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    Buenos Aires, C1199ABB, Argentina

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    Buenos Aires, C1428, Argentina

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    Rosario, S2000DEJ, Argentina

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    Bedford Park, 5042, Australia

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    Box Hill, 3128, Australia

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    Chermside, 4032, Australia

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    Darlinghurst, 2010, Australia

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    Joondalup, 6027, Australia

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    Braunau am Inn, 5280, Austria

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    Graz, 8036, Austria

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    Wels, 4600, Austria

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    Aalst, 9300, Belgium

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    Brussels, 1200, Belgium

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    Dendermonde, 9200, Belgium

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    Ghent, 9000, Belgium

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    Hasselt, 3500, Belgium

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    Leuven, 3000, Belgium

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    Liège, 4000, Belgium

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    Roeselare, 8800, Belgium

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    Belo Horizonte, 30220-140, Brazil

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    Porto Alegre, 90035-903, Brazil

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    Ribeirão Preto, 14051-140, Brazil

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    São Paulo, 05403-000, Brazil

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    London, N6A 5A5, Canada

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    Aarhus N, 8200, Denmark

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    København Ø, 2100, Denmark

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    Odense C, 5000, Denmark

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    Chambray-lès-Tours, 37170, France

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    La Tronche, 38700, France

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    Marseille, 13005, France

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    Montpellier, 34295, France

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    Paris, 75015, France

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    Pessac, 33600, France

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    Reims, 51100, France

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    Rennes, 35000, France

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    Rouen, 76031, France

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    Saint-Herblain, 44093, France

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    Toulouse, 31059, France

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    Berlin, 13353, Germany

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    Hanover, 30625, Germany

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    Leipzig, 04103, Germany

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    Munich, 81377, Germany

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    Münster, 48149, Germany

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    Würzburg, 97080, Germany

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    Athens, 115 27, Greece

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    Athens, 115 28, Greece

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    Heraklion, 714 09, Greece

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    Thessaloniki, 546 36, Greece

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    Hong Kong, 999077, Hong Kong

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    Be’er Ya‘aqov, 70300, Israel

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    Haifa, 3109601, Israel

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    Jerusalem, 91120, Israel

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    Petah Tikva, 4941492, Israel

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    Ancona, 60126, Italy

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    Brescia, 25123, Italy

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    Florence, 50134, Italy

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    Forlì, 47121, Italy

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    Naples, 80131, Italy

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    Pavia, 27100, Italy

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    Pisa, 56124, Italy

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    Rimini, 47923, Italy

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    Roma, 00168, Italy

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    Bunkyō City, 113-8655, Japan

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    Fukuoka, 810-0001, Japan

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    Fukuoka, 812-8582, Japan

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    Kagawa, 761-0793, Japan

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    Kashihara, 634-8522, Japan

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    Kobe, 650-0017, Japan

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    Kumamoto, 860-8556, Japan

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    Kurume, 830-0011, Japan

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    Matsumoto-shi, 390-8621, Japan

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    Nankoku, 783-0043, Japan

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    Niigata, 951-8520, Japan

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    Okayama, 700-8558, Japan

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    Sapporo, 060-8543, Japan

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    Sapporo, 060-8648, Japan

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    Sendai, 980-8574, Japan

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    Kajang, 43000, Malaysia

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    Eindhoven, 5623 EJ, Netherlands

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    Groningen, 9713 GZ, Netherlands

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    Rotterdam, 3015 GD, Netherlands

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    Utrecht, 3584 CX, Netherlands

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    Christchurch, 8011, New Zealand

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    Hamilton, 3204, New Zealand

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    Carnaxide, 2790-134, Portugal

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    Creixomil, 4835-044, Portugal

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    Leiria, 2410-197, Portugal

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    Lisbon, 1169-024, Portugal

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    Lisbon, 1649-035, Portugal

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    Vila Real, 5000-508, Portugal

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    Viseu, 3504-509, Portugal

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    Incheon, 22332, South Korea

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    Seoul, 03080, South Korea

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    Seoul, 03722, South Korea

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    Seoul, 06351, South Korea

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    Seoul, 06591, South Korea

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    A Coruña, 15006, Spain

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    Barcelona, 08035, Spain

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    Barcelona, 08036, Spain

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    Bilbao, 48013, Spain

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    El Palmar, 30120, Spain

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    Huelva, 21005, Spain

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    Jaén, 23007, Spain

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    L'Hospitalet de Llobregat, 8907, Spain

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    Lleida, 25198, Spain

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    Madrid, 28046, Spain

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    Madrid, 28222, Spain

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    Palma de Mallorca, 07198, Spain

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    Pamplona, 31008, Spain

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    Salamanca, 37007, Spain

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    Santiago de Compostela, 15706, Spain

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    Valencia, 46010, Spain

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    Valencia, 46026, Spain

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    Vigo, 36213, Spain

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    Gothenburg, 413 45, Sweden

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    Lund, 222 42, Sweden

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    Solna, 171 76, Sweden

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    Basel, 4051, Switzerland

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    Genève, 1205, Switzerland

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    Lucerne, 6000, Switzerland

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    Sankt Gallen, 9007, Switzerland

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    New Taipei City, 220, Taiwan

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    Taipei, 10002, Taiwan

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    Taipei, 112, Taiwan

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    Bellshill, ML4 3NJ, United Kingdom

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    Birmingham, B15 2SQ, United Kingdom

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    Cardiff, CF15 9SS, United Kingdom

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    London, NW10 2PB, United Kingdom

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    London, NW3 2QG, United Kingdom

  • Clinical Trial Site

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    Manchester, M15 6SE, United Kingdom

Conditions

Explore the condition pages connected to this study.

TRANSTHYRETIN AMYLOIDOSIS WITH CARDIOMYOPATHY