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New Two-Pronged attack on tough head & neck cancers enters testing

NCT ID NCT06727565

Ongoing Disease control Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

Summary

This study is testing if adding a second immunotherapy drug (domvanalimab) to a standard treatment (zimberelimab plus chemotherapy) works better for people with advanced head and neck cancer that has returned or spread. It will involve about 100 participants who have not yet received treatment for their advanced cancer. The main goals are to see if the two-drug combo shrinks tumors more effectively and keeps the cancer from worsening for a longer time.

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Contacts and locations

Locations

  • Alfred Health

    Melbourne, Victoria, 3004, Australia

  • Barts Health NHS Foundation Trust

    London, EC1A 7BE, United Kingdom

  • CHU de Bordeaux

    Pessac, 33604, France

  • Chang Gung Memorial Hospital, Linkou

    Taoyuan District, 33308, Taiwan

  • China Medical University Hospital

    Taichung, 40402, Taiwan

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, 20133, Italy

  • Guangxi Medical University Cancer Hospital

    Nanning, 530012, China

  • Hospital Universitario Virgen del Rocio

    Seville, 41013, Spain

  • ICON Cancer Center

    Kurralta Park, South Australia, 5037, Australia

  • Istituto Nazionale Tumori Fondazione G. Pascale

    Naples, 80131, Italy

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 80756, Taiwan

  • Monash Health

    Clayton, Victoria, 3168, Australia

  • Sarawak General Hospital

    Sarawak, 93586, Malaysia

  • Shanghai East Hospital

    Shanghai, 200120, China

  • Sichuan Cancer Hospital

    Chengdu, 610040, China

  • Siteman Cancer Center

    St Louis, Missouri, 63110, United States

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • Tennessee Oncology, PLLC - Greco-Hainsworth Centers for Research

    Nashville, Tennessee, 37203, United States

  • The Royal Marsden NHS Foundation Trust

    London, SW10 9NH, United Kingdom

  • The University of Texas, MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, 430030, China

  • Westmead Hospital

    Sydney, New South Wales, 2145, Australia

  • Zhejiang Cancer Hospital

    Hangzhou, 310005, China

Conditions

Explore the condition pages connected to this study.

HEAD AND NECK SQUAMOUS CELL CARCINOMA