Can a gentle brain current quiet alcohol cravings?
NCT ID NCT07808190
First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time
Summary
This trial tests whether a non-invasive brain stimulation technique called HD-tACS can reduce alcohol cravings and help prevent relapse in people with alcohol use disorder. Participants receive either real or sham stimulation for 20 minutes, three times a day, over 10 days. Researchers measure changes in craving, impulsivity, and learning patterns to see if the treatment has a lasting effect.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- High-definition transcranial alternating current stimulation (HD-tACS), a non-invasive brain stimulation device
- What this could lead to
- If effective, this could offer a drug-free way to curb alcohol cravings and lower relapse risk after detoxification.
- What could go wrong
- The trial is early and small, and results may not hold for everyone. Brain stimulation can cause mild discomfort, and its long-term benefits remain unproven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 140 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age range: 18-55 years old, gender not restricted; * Meets the DSM-5 diagnostic criteria for alcohol use disorder (moderate to severe); * AUDIT score ≥ 16; * Baseline score after alcohol cue-induced stimulation is ≥ 3; * Completed detoxification treatment before enrollment (moderate to severe), with detoxification duration of ≥ 7 days and ≤ 90 days; * Has a primary school education or above, and can understand and complete the research assessment; * Voluntarily participated in the study and signed the informed consent form. Exclusion Criteria: * Currently, there are other substance use disorders (except nicotine); * Currently, there are schizophrenia, bipolar disorder or other severe psychotic disorders; * Has a history of epilepsy or family history of epilepsy; * Has a history of brain trauma, brain surgery or intracranial metal implants; * Has received electroconvulsive therapy (ECT), transcranial electrical/magnetic/ultrasound stimulation within the past 6 months; * Pregnant or lactating women; * Other situations that the researchers consider unsuitable for participation in this study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Shanghai Mental Health Center
Shanghai, Shanghai Municipality, 200000, China
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Other studies related to the condition(s) this trial covers.
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- Intravenous acetate as an adjunctive treatment for alcohol withdrawal in hospitalized patients
- Brain imaging may expose a shared marker in PTSD and alcohol addiction
- Could a seizure drug curb alcohol withdrawal in trauma wards?
- Can a brain zapping headset curb relapse in addiction?