Cow-Hemoglobin infusion could save lives when blood is not an option
NCT ID NCT03633604
First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time
Summary
This study tests HBOC-201, an oxygen-carrying fluid made from cow hemoglobin, in adults with life-threatening anemia who cannot receive red blood cell transfusions. Participants have dangerously low hemoglobin levels and signs of oxygen deprivation. The goal is to see if HBOC-201 can temporarily deliver oxygen to tissues and reduce the need for blood transfusions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HBOC-201, also called Hemopure, a hemoglobin-based oxygen carrier made from cow blood
- What this could lead to
- If it works, HBOC-201 could provide a life-saving oxygen bridge for patients with severe anemia who cannot or will not accept blood transfusions.
- What could go wrong
- This is an expanded-access study, not a controlled trial, so results may not prove broad effectiveness. HBOC-201 carries risks like high blood pressure and kidney injury.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States