New hope for Never-Smokers with lung cancer: experimental drug combo targets resistant tumors

NCT ID NCT05456256

First seen Oct 31, 2025 · Last updated May 12, 2026 · Updated 26 times

Summary

This study tests whether adding an experimental drug called LP-300 to standard chemotherapy can help people who never smoked but have advanced lung cancer that stopped responding to targeted therapy. About 90 participants will receive either the drug combo or chemo alone. The goal is to see if the combination slows cancer growth and extends life.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Cancer and Blood Specialists Clinic

    SUSPENDED

    Los Alamitos, California, 90720, United States

  • Chi Mei Medical Center

    RECRUITING

    Tainan, Taiwan

    Contact

    Contact Email: •••••@•••••

  • Fox Chase Cancer Center

    RECRUITING

    Philadelphia, Pennsylvania, 19111, United States

    Contact

    Contact Email: •••••@•••••

  • Hokkaido Cancer Center

    ACTIVE_NOT_RECRUITING

    Sapporo, Hokkaido, Japan

  • Inova Fairfax Hospital

    RECRUITING

    Fairfax, Virginia, 22031, United States

    Contact

    Contact

    Contact

    Contact Email: •••••@•••••

    Contact

  • Kanagawa Cancer Center Hospital

    ACTIVE_NOT_RECRUITING

    Yokohama, Kanagawa, Japan

  • Los Angeles Cancer Network

    RECRUITING

    Fountain Valley, California, 92708, United States

    Contact Email: •••••@•••••

    Contact

  • National Cancer Center Hospital

    ACTIVE_NOT_RECRUITING

    Chuo-ku, Tokyo, Japan

  • National Cheng Kung University Hospital

    RECRUITING

    Tainan, Taiwan

    Contact

    Contact Email: •••••@•••••

  • National Taiwan University Hospital Hsin-Chu Branch

    RECRUITING

    Hsinchu, Taiwan

    Contact Email: •••••@•••••

    Contact

  • Okayama University Hospital

    ACTIVE_NOT_RECRUITING

    Okayama, Okayama-ken, Japan

  • Precision NextGen Oncology and Research Center

    RECRUITING

    Beverly Hills, California, 90212, United States

    Contact

    Contact Email: •••••@•••••

  • Taipei Veterans General Hospital

    RECRUITING

    Taipei, Taiwan

    Contact Email: •••••@•••••

    Contact

  • Tohoku University Hospital

    ACTIVE_NOT_RECRUITING

    Sendai, Miyagi, Japan

  • TriService General Hospital-Neihu Main Facility

    RECRUITING

    Taipei, Taiwan

    Contact

    Contact Email: •••••@•••••

  • UT Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75235, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.