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Hidden in the gut: scientists hunt the everyday exposures behind Drug-Resistant bacteria

NCT ID NCT07818109

Knowledge-focused Sponsor: Hospital Italiano de Buenos Aires Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers in Argentina are studying why some healthy adults carry extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales in their gut without being sick. The team will collect rectal swabs, stool, and urine from 432 community-dwelling adults and ask detailed questions about healthcare contact, antibiotic use, animal contact, water access, diet, and pesticide exposure. Samples will be stored for future molecular and microbiome analysis. The goal is to understand which biological, occupational, and environmental factors are linked to carrying these resistant bacteria, so public health strategies can better prevent their spread.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If researchers identify which exposures raise the odds of carrying resistant gut bacteria, public health programs could target those risks and help slow the spread of hard-to-treat infections.
What could go wrong
This study only observes people at one point in time, so it can show links but not prove cause and effect. The findings may not apply to other regions or countries with different diets, water systems, and antibiotic use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 432 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of community-dwelling adults from selected territorial regions of Argentina recruited through sentinel healthcare facilities. Participants will be identified among adults attending outpatient clinics, emergency departments, or hospitalized for less than 24 hours, as well as accompanying family members or caregivers when applicable. Recruitment will be performed using a quota-based sampling strategy designed to achieve representation according to age, sex, and geographic area. The initial phase of the study will be conducted at Hospital Italiano de Buenos Aires and Hospital J. B. Iturraspe (Santa Fe Province), representing distinct territorial and socio-environmental contexts.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. * Resident for at least 1 year in one of the territorial areas included in the study. * Community-dwelling individuals attending participating healthcare facilities (outpatient clinics, emergency departments, or hospitalized for less than 24 hours) or their accompanying family members/caregivers. * Able and willing to provide informed consent. * Able to provide fecal and urine samples. Exclusion Criteria: * Hospitalization within the previous 6 months. * Antibiotic treatment within the previous 6 months. * Current or recent oncologic treatment, immunotherapy, or immunosuppressive therapy within the previous 6 months. * Use of laxatives within the previous 15 days. * Pregnancy or breastfeeding. * Inability to provide informed consent. * Residence outside the study territorial areas.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Antimicrobial resistance (AMR) Carbapenemase-producing enterobacterales (CPE) colonization Carbapenemase-producing enterobacteriaceae Carbapenemase-producing enterobacteriaceae (CPE) Environmental exposure ESBL Gut microbiota dysbiosis

How to take part

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  1. The places running it

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  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

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  3. A doctor treating you

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Contacts and locations

Locations

  • Hospital Italiano de Buenos Aires

    Buenos Aires, Buenos Aires F.D., 1199, Argentina

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