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A blood injection to erase black triangles between teeth?

NCT ID NCT06842277

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial tests whether an injectable substance made from a patient's own blood — albumin-platelet rich fibrin — can rebuild the small triangle of gum tissue that is sometimes missing between teeth, creating an unappealing dark gap. The study includes people with mild to moderate gum tissue loss in the front teeth who are otherwise healthy. Researchers will measure how much the black triangle shrinks after treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
injectable albumin-platelet rich fibrin (a substance made from the patient's own blood to promote tissue growth)
What this could lead to
If effective, this minimally invasive injection could offer a way to fill in unsightly black triangles between teeth without surgery.
What could go wrong
This is a very small early-phase trial with only 10 participants, so results may not apply to everyone. The treatment may not produce lasting improvement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

10 people

The number who actually took part.

Started

Feb 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients' complaint from poor esthetics and unappealing black triangles in anterior sextant. * Patients had well -aligned maxillary teeth, no caries, no proximal restoration, fixed prosthesis, or any orthodontic appliance. * Patients had at least one class 1or 2 interdental papilla loss in maxillary or mandibular anterior regions. * Patients had at selected sites, distance between contact point and inter proximal bone crest less than 7mm and probing depth less than 4mm. * Patients had plaque index and gingival index less than 1. Exclusion Criteria: * Patient had advanced periodontal problems (advanced bone and soft tissue loss). * Patients had a systemic condition affect blood components and healing. * Smoker patients. * Patients who are pregnant.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Deficient interdental papilla Interdental papilla reconstruction

Contacts and locations

Locations

  • Faculty of Dentistry , Cairo University

    Giza, Giza Governorate, 12613, Egypt

  • Faculty of Dentistry Cairo University

    Giza, Giza Governorate, 12613, Egypt

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