Gene therapy trial for blinding eye disease halted

NCT ID NCT04566445

Terminated Disease control Sponsor: Gyroscope Therapeutics Limited Source: ClinicalTrials.gov ↗

Summary

This study tested whether a single injection of an experimental gene therapy called GT005 could slow the progression of geographic atrophy, a form of advanced dry age-related macular degeneration (AMD) that causes permanent vision loss. About 255 participants with this condition were assigned to receive one of two doses of the injection or no treatment, and their eye health was tracked for up to 96 weeks. The trial was terminated early because an independent committee determined it was unlikely to show a meaningful benefit for patients.

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Contacts and locations

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Locations

Associated Retinal Consultants PC

Royal Oak, Michigan, 48073, United States
Austin Research Center for Retina, PLLC

Austin, Texas, 78705, United States
Bascom Palmer Eye Institute

Miami, Florida, 33136, United States
Byers Eye Institute at Stanford

Palo Alto, California, 94303, United States
CHU Dijon - Hopital Mitterrand

Dijon, 21000, France
CHU de Nantes - Hôtel-Dieu

Nantes, 44093, France
Casey Eye Institute - OHSU

Portland, Oregon, 97239, United States
Centre Paradis Monticelli

Marseille, 13008, France
Charles Retina Institute

Germantown, Tennessee, 38138, United States
Cincinnati Eye Institute

Cincinnati, Ohio, 45242, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Clinica Baviera

Madrid, 28046, Spain
Clinica Universidad de Navarra - Pamplona

Pamplona, 31008, Spain
Columbia University Medical Center

New York, New York, 10032, United States
Department of Ophthalmology UW Medicine

Seattle, Washington, 98104-2499, United States
Duke Eye Center

Durham, North Carolina, 27705, United States
Erie Retinal Surgery ,INC

Erie, Pennsylvania, 16507, United States
Georgia Retina PC

Marietta, Georgia, 30060, United States
Illinois Retina Associates

Chicago, Illinois, 60657, United States
Instituto de microcirugía ocular

Barcelona, 08035, Spain
Internationale Innovative Ophthalmochirurgie

Düsseldorf, 40549, Germany
John Radcliffe Hospital

Oxford, OX3 9DU, United Kingdom
Mid Atlantic Retina - Wills Eye Hospital

Philadelphia, Pennsylvania, 19107, United States
Midwest Eye Institute Northside

Indianapolis, Indiana, 46290, United States
Moorfields Eye Hospital - NHS Foundation Trust

London, EC1V 2PD, United Kingdom
Northern California Retina Vitreous Associates

Mountain View, California, 94040, United States
Oftalmika Spolka z ograniczona odpowiedzialnoscia

Bydgoszcz, 85-631, Poland
Ophthalamic Consultants of Boston (OCB)

Boston, Massachusetts, 02114, United States
Oregon Retina

Eugene, Oregon, 97401, United States
Palmetto Retina Center

West Columbia, South Carolina, 29169, United States
Rand Eye Institute

Deerfield Beach, Florida, 33064, United States
Retina Associates of Michigan

Grand Blanc, Michigan, 48439, United States
Retina Associates of Western New York

Rochester, New York, 14620, United States
Retina Associates, LLC

Shawnee Mission, Kansas, 66204, United States
Retina Center Northwest

Silverdale, Washington, 98383, United States
Retina Clinic London

London, W1G 7LB, United Kingdom
Retina Consultants of Houston

The Woodlands, Texas, 77384, United States
Retina Consultants of Houston-TMC

Bellaire, Texas, 77401, United States
Retina Consultants of Orange County

Fullerton, California, 92835, United States
Retina Consultants of San Diego

Poway, California, 92064, United States
Retina Foundation of the Southwest

Dallas, Texas, 75231, United States
Retina Vitreous Associates Medical Group

Beverly Hills, California, 90211, United States
Retina Vitreous Associates of Florida

St. Petersburg, Florida, 33711, United States
Retinal Consultants of San Antonio

San Antonio, Texas, 78240, United States
Retinal Research Institute (retina consultants of AZ)

Phoenix, Arizona, 85053, United States
Rocky Mountain Retina Consultants

Salt Lake City, Utah, 84107, United States
Sierra Eye Associates

Reno, Nevada, 89502, United States
Southeast Retina Center

Augusta, Georgia, 30909, United States
Southeastern Retina Associates, PC

Knoxville, Tennessee, 37922, United States
Southwest Retina Research Center

Durango, Colorado, 81303, United States
Sunderland Eye Infirmary

Sunderland, SR2 9HP, United Kingdom
Sydney Hospital and Sydney Eye Hospital

Sydney, New South Wales, 2000, Australia
Texas Retina Associates (Dallas)

Dallas, Texas, 75231, United States
The Retina Care Center

Baltimore, Maryland, 21209, United States
The University of Melbourne - The Centre for Eye Research Australia (CERA)

Melbourne E., Victoria, 3002, Australia
Universitaetsklinikum Schleswig-Holstein - Campus Lübeck

Lübeck, 23562, Germany
Universitaetsklinikum Tuebingen

Tübingen, 72076, Germany
University Retina Macula Associates PC

Lemont, Illinois, 60452, United States
University of California (UC) Davis Medical Group Eye Center

Sacramento, California, 95817, United States
Universitätsklinikum Bonn

Bonn, 53127, Germany
VitreoRetinal Associates, P.A.

Gainesville, Florida, 32607, United States
Wolfe Eye Clinic

West Des Moines, Iowa, 50266, United States

Conditions

Explore the condition pages connected to this study.

DRY AGE-RELATED MACULAR DEGENERATION