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Lupus skin drug trial halted early – what we know

NCT ID NCT05629208

Terminated Disease control Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an experimental oral drug called edecesertib (GS-5718) in 20 people with cutaneous lupus erythematosus, a condition where lupus affects the skin. The goal was to see if the drug could reduce skin disease activity and improve symptoms. However, the trial was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Edecesertib (also called GS-5718), an oral tablet
What this could lead to
If successful, this could point toward a new treatment option for people with cutaneous lupus erythematosus, a skin condition caused by lupus.
What could go wrong
This was a very small, early-phase study that was terminated early, so we don't know if the drug works or is safe. The results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cutaneous lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CUTANEOUS LUPUS ERYTHEMATOSUS (CLE)

Contacts and locations

Locations

  • ARENSIA Exploratory Medicine, LLC

    Phoenix, Arizona, 85015, United States

  • Center for Dermatology Clinical Research Inc.

    Fremont, California, 94538, United States

  • Clinical Investigations of Texas

    Plano, Texas, 75075, United States

  • Clinical Research of West Florida, Inc.

    Clearwater, Florida, 33765, United States

  • Dawes Fretzin Clinical Research Group, LLC

    Indianapolis, Indiana, 46250, United States

  • Dept. of Dermatology, Hospital of the University of Pennsylvania, Perelman Center for Advanced Medicine (PCAM)

    Philadelphia, Pennsylvania, 19104, United States

  • Emory University School of Medicine

    Atlanta, Georgia, 30303, United States

  • Gulf Bank Medical Center

    Houston, Texas, 77037, United States

  • HMD Research LLC

    Orlando, Florida, 32819, United States

  • Hospital General de Granollers

    Granollers, 08402, Spain

  • Hospital Universitario de Navarra

    Pamplona, 31008, Spain

  • Reliant Medical Research

    Miami, Florida, 33165, United States

  • Universitatsklinikum Freiburg Klinik fur Dermatologie und Venerologie

    Freiburg im Breisgau, 79104, Germany

  • University of Colorado, Barbara Davis Center, Center for Clinical Research

    Aurora, Colorado, 80045, United States

  • Universitätsklinikum Carl Gustav Carus Klinik und Poliklinik für Dermatologie

    Dresden, 01307, Germany

  • Universitätsklinikum Leipzig AöR Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie Klinische Forschungseinheit (KFE) - Haus 10

    Leipzig, 04103, Germany

  • Yale Center for Clinical Investigation (YCCI)

    New Haven, Connecticut, 06510, United States

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