New drug targets rare gene fault in advanced cancers

NCT ID NCT07128303

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a new drug called GS-5319 in adults with advanced solid tumors that lack a specific gene (MTAP). The main goals are to check the drug's safety, find the best dose, and see how the body processes it. About 178 people whose cancer has not responded to standard treatments will take part.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Asan Medical Center

    RECRUITING

    Seoul, 05505, South Korea

  • Beth Israel Deaconess Medical Center

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • NEXT Virginia

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • START - Centro Oncológico Clara Campal

    RECRUITING

    Madrid, 28050, Spain

  • START Madrid - FJD - Hospital Fundación Jiménez Díaz - Phase I Clinical Trials Unit

    RECRUITING

    Madrid, 28040, Spain

  • START San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

  • Samsung Medical Center

    RECRUITING

    Seoul, 06351, South Korea

  • Seoul National University Hospital

    RECRUITING

    Seoul, 03080, South Korea

  • Vall d'Hebron Institute of Oncology (VHIO)

    RECRUITING

    Barcelona, 08035, Spain

  • Yonsei University Severance Hospital

    RECRUITING

    Seoul, '06273, South Korea

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