Could a cotton plant compound help beat drug-resistant colon cancer?

NCT ID NCT07337551

First seen Jan 13, 2026 · Last updated Apr 30, 2026 · Updated 16 times

Summary

This study tests a combination of three drugs—gossypol acetate (from cotton plants), bevacizumab, and FOLFIRI—in 20 adults with a specific type of advanced colorectal cancer that has a TP53 mutation and LRPPRC protein. The goal is to see if this mix can shrink tumors or slow the cancer after first-line treatment failed. Participants will receive the combo until the cancer worsens or side effects become too severe.

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