New antibody weapon targets Hard-to-Treat blood cancers

NCT ID NCT04606433

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 23 times

Summary

This early-phase study tests a new drug called GNC-038, a quad-specific antibody designed to attack cancer cells in people with relapsed or refractory non-Hodgkin's lymphoma or acute lymphoblastic leukemia. The main goals are to check the drug's safety, find the right dose, and see if it shrinks tumors. About 47 adults will take part in this open-label, multicenter trial.

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Contacts and locations

Locations

  • Chongqing University Cancer Hospital

    Chongqing, Chongqing Municipality, China

  • Guangdong Provincial People's Hospital

    Guangzhou, Guangdong, China

  • Hematology Hospital, Chinese Academy of Medical Sciences

    Tianjin, Tianjin Municipality, 300000, China

  • Nanfang Hospital of Southern Medical University

    Guangzhou, Guangdong, China

  • Peking University Third Hospital

    Beijing, Beijing Municipality, China

  • Shanghai Tongji Hospital

    Shanghai, Shanghai Municipality, China

  • The First Affiliated Hospital of Chongqing Medical University

    Chongqing, Chongqing Municipality, China

  • The Second Affiliated Hospital Zhejiang University School of Medicine

    Hangzhou, Zhejiang, China

  • The Second Hospital of Anhui Medical University

    Hefei, Anhui, China

  • Xiangya Hospital Central South University

    Changsha, Hunan, China

Conditions

Explore the condition pages connected to this study.