Can sleep or nerve stimulation clean the brain? new trial for CAA patients
NCT ID NCT06421532
First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 27 times
Summary
This study tests whether a sleep-deepening drug (lower-sodium oxybate) or a nerve stimulation device (non-invasive vagus nerve stimulation), or both, can help the brain clear harmful proteins in people with cerebral amyloid angiopathy (CAA). Sixty adults with CAA will receive one or both treatments for a period. The main goal is to measure changes in protein levels in spinal fluid, and MRI scans will track brain health. The study aims to find new ways to slow the disease.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Leiden University Medical Center (LUMC)
Leiden, 2333ZA, Netherlands
Conditions
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