New drug offers hope for lymphoma patients who failed CAR T-Cell therapy
NCT ID NCT07453095
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial is testing a drug called glofitamab in 41 people with mantle cell lymphoma whose cancer did not respond or came back after CAR T-cell therapy. The goal is to see if glofitamab can shrink or control the cancer. Researchers will measure how many patients achieve a complete response (no cancer detected) during treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Glofitamab
What this could lead to
If successful, glofitamab could offer a new treatment option for mantle cell lymphoma patients who have not responded to or relapsed after CAR T-cell therapy.
What could go wrong
This is a small, early-phase trial (Phase 2) with only 41 participants, so results may not apply to all patients. Glofitamab may cause side effects, and it is not expected to cure the disease; ongoing management may still be needed.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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A.O. Ospedali Riuniti Villa Sofia-Cervello - Divisione di Ematologia
NOT_YET_RECRUITINGPalermo, Italy
Contact Email: •••••@•••••
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A.O.U. Città della Salute e della Scienza - Ematologia Universitaria
NOT_YET_RECRUITINGTorino, Italy
Contact Email: •••••@•••••
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AOU SS. Antonio e Biagio e Cesare Arrigo - SCDU Ematologia
NOT_YET_RECRUITINGAlessandria, Italy
Contact Email: •••••@•••••
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ASST Grande Ospedale Metropolitano Niguarda - SC Ematologia
NOT_YET_RECRUITINGMilan, Italy
Contact Email: •••••@•••••
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ASST Spedali Civili - Ematologia
NOT_YET_RECRUITINGBrescia, Italy
Contact Email: •••••@•••••
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Azienda Ospedaliera Universitaria Careggi - Unità funzionale di Ematologia
NOT_YET_RECRUITINGFlorence, Italy
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Azienda Ospedaliera Universitaria Integrata di Verona - U.O. Ematologia
NOT_YET_RECRUITINGVerona, Italy
Contact Email: •••••@•••••
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Azienda Ospedaliera Universitaria Pisana - U.O. Ematologia
NOT_YET_RECRUITINGPisa, Italy
Contact Email: •••••@•••••
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Grande Ospedale Metropolitano Bianchi Melacrino Morelli - C.T.M.O.
RECRUITINGReggio Calabria, Italy
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Ospedale Policlinico San Martino S.S.R.L. - IRCCS per l'Oncologia - Ematologia e terapie cellulari
NOT_YET_RECRUITINGGenova, Italy
Contact Email: •••••@•••••
Contact
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P.O. Spirito Santo di Pescara - UOC Ematologia Dipartimento Oncologico Ematologico - ASL Pescara
NOT_YET_RECRUITINGPescara, Italy
Contact Email: •••••@•••••
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Policlinico S.Orsola-Malpighi - Istituto di Ematologia Seragnoli
NOT_YET_RECRUITINGBologna, Italy
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Policlinico Umberto I - Universitа "La Sapienza" - Istituto Ematologia -Dipartimento di Medicina Traslazionale e di Precisione
NOT_YET_RECRUITINGRoma, Italy
Contact Email: •••••@•••••
Contact
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ULSS 8 Berica - Ospedale S. Bortolo - Ematologia
NOT_YET_RECRUITINGVicenza, Italy
Contact Email: •••••@•••••
Contact