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Can genetics predict the worsening of geographic atrophy?

NCT ID NCT02479386

Knowledge-focused Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This study follows people with geographic atrophy, a severe form of age-related macular degeneration that causes blind spots, to see how their vision changes over time. Researchers will measure visual function, such as reading speed and sensitivity to light, and track the growth of the affected area in the eye. They will also look at genetic factors that might influence how quickly the condition progresses. The goal is to better understand the disease and potentially inform future treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
This research could improve understanding of how geographic atrophy progresses, potentially guiding future treatments and clinical trial designs.
What could go wrong
As an observational study, it does not test a treatment, so it cannot directly lead to a cure. The findings may also be limited by the specific group of participants studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

296 people

The number who actually took part.

Started

Jun 2015

Finished

Jan 2018

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive methods that result in a failure rate of less than (\<) 1 percent (%) per year for at least 30 days after the last fluorescein dye administration * The study is being conducted in participants with GA in both Study Eye and Non-Study Eye (bilateral GA) with no evidence of prior or active choroidal neovascularization (CNV) Exclusion Criteria: * Previous participation in any studies of investigational drugs for GA or dry AMD (except for studies of vitamins and minerals) * GA in either eye due to causes other than AMD * History of vitrectomy surgery, submacular surgery, or any surgical intervention for AMD * Previous laser photocoagulation for CNV, diabetic macular edema, retinal vein occlusion, and/or proliferative diabetic retinopathy * Any ocular or systemic medical conditions that, in the opinion of the investigator, could contribute to participant's inability to participate in the study or interfere with study assessments * Requirement for continuous use of therapy indicated in Prohibited Therapy in the study Protocol

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Conditions

The condition(s) this trial relates to.

dry age related macular degeneration Geographic Atrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Geographic atrophy

Contacts and locations

Locations

  • ASST FATEBENEFRATELLI SACCO; Oculistica (Sacco)

    Milan, Lombardy, 20157, Italy

  • Azienda Ospedaliero-Universitaria Careggi; S.O.D. Oculistica

    Florence, Tuscany, 50134, Italy

  • Bajcsy-Zsilinszky Hospital

    Budapest, 1106, Hungary

  • Bascom Palmer Eye Institute

    Naples, Florida, 34103, United States

  • Botelho Hospital da Visao

    Blumenau, Santa Catarina, 89052-504, Brazil

  • Bristol Eye Hospital

    Bristol, BS1 2LX, United Kingdom

  • CHNO des Quinze Vingts; Ophtalmologie

    Paris, 75012, France

  • CHU Poitiers - CHR La Miletrie; Ophtalmologie

    Poitiers, 86021, France

  • Cabinet La Maison Rouge; Ophtalmologie

    Strasbourg, 67000, France

  • Calgary Retina Consultants

    Calgary, Alberta, T2J 0C8, Canada

  • Center For Sight

    Sarasota, Florida, 34239, United States

  • Centre Paradis Monticelli; Ophtalmologie

    Marseille, 13008, France

  • Centre ophtalmologique Rabelais; Ophtalmologie

    Lyon, 69003, France

  • Centres Ophtalmologique St Exupéry; Ophtalmologie

    Saint-Cyr-sur-Loire, 37540, France

  • Centro Oftalmólogos Especialistas

    Rosario, S2000ANJ, Argentina

  • Centro Privado de Ojos Romagosa

    Córdoba, Argentina

  • Chaim Sheba Medical Center

    Ramat Gan, 5265601, Israel

  • Char Eye Ear &Throat Assoc

    Charlotte, North Carolina, 28210, United States

  • Chi De Creteil; Ophtalmologie

    Créteil, 94010, France

  • Clinica Doctores Piñero; Oftalmologia

    Seville, SEVILLA, 41013, Spain

  • Clinica Privada de Ojos

    Mar del Plata, B7600DFC, Argentina

  • Clinique de la Louviere - Nord retine; Maladie et chirurgie des Yeux

    Lille, 59000, France

  • Colorado Retina Associates, PC

    Golden, Colorado, 80401, United States

  • Duke University Eye Center; Vitreoretinal

    Durham, North Carolina, 27710, United States

  • East Bay Retina Consultants

    Oakland, California, 94609, United States

  • European Interbalkan Medical Center; Ophthalmology Dpt

    Thessaloniki, 57001, Greece

  • Fondation Rothschild; Ophtalmologie

    Paris, 75940, France

  • Foundation for Vision Research

    Grand Rapids, Michigan, 49546, United States

  • Greater Baltimore Medical Center

    Baltimore, Maryland, 21204, United States

  • Hadassah MC; Ophtalmology

    Jerusalem, 9112001, Israel

  • Hopital Lariboisiere; Ophtalmologie

    Paris, 75010, France

  • Hosp Clinicas da FMUSP

    São Paulo, São Paulo, 05403-000, Brazil

  • Hospital Clinico Universitario de Valladolid; Servicio de oftalmologia

    Valladolid, VALLADOLID, 47005, Spain

  • Hospital Universitario Rio Hortega; Servicio de Oftalmologia

    Valladolid, VALLADOLID, 47012, Spain

  • Hospital Universitario Virgen de la Macarena; Servicio de Oftalmologia

    Seville, SEVILLA, 41007, Spain

  • Hospital de Olhos de Aparecida - HOA

    Aparecida de Goiânia, Goiás, 74980-010, Brazil

  • Hospital de la Santa Creu i Sant Pau; Servicio de Oftalmologia

    Barcelona, BARCELONA, 8025, Spain

  • Hull and East Yorkshire Eye Hospital

    Hull, HU32J, United Kingdom

  • Institut De L'Oeil Des Laurentides

    Boisbriand, Quebec, J7H 1S6, Canada

  • Institut de la Macula i la retina

    Barcelona, BARCELONA, 08022, Spain

  • Instituto da Visão

    Belo Horizonte, Minas Gerais, 30150-270, Brazil

  • Instituto da Visão IPEPO

    São Paulo, São Paulo, 04038-032, Brazil

  • John Radcliffe Hospital; Oxford Eye Hospital

    Oxford, OX3 9DU, United Kingdom

  • Jules Stein Eye Institute/ UCLA

    Los Angeles, California, 90095-7000, United States

  • Kaplan Medical Center; Ophtalmology

    Rehovot, 7660101, Israel

  • Kenezy Gyula Korhaz; Szemeszet

    Debrecen, 4031, Hungary

  • Kent & Canterbury Hospital

    Canterbury, CT1 3NG, United Kingdom

  • Klinika Okulistyki Ogolnej w Lublinie

    Lublin, 20-079, Poland

  • Klinikum rechts der Isar der TU München; Augenklinik

    München, 81675, Germany

  • MaculaCare, PLLC

    New York, New York, 10021, United States

  • Magyar Honvedseg Egeszsegugyi Kozpont; Fázis I-es Klinikai Farmakológiai Vizsgálóhely

    Budapest, H-1077, Hungary

  • Markusovszky Egyetemi Oktatokorhaz ; SZEMESZET

    Szombathely, 9700, Hungary

  • Med Center Ophthalmology Assoc

    San Antonio, Texas, 78240, United States

  • Medizinische Universität Wien; Universitätsklinik für Augenheilkunde und Optometrie

    Vienna, 1090, Austria

  • Meir Medical Center; Ophtalmology

    Kfar Saba, 4428164, Israel

  • Newcastle Eye Hospital Research Foundation

    Waratah, New South Wales, 2298, Australia

  • Northern Beaches Retina Cataract Glaucoma

    Mona Vale, New South Wales, 2103, Australia

  • Northwest Arkansas Retina Associates

    Springdale, Arkansas, 72764, United States

  • Nuovo Ospedale S. Chiara - A.O.U.P Presidio Ospedaliero di Cisanello; U.O. Oculistica Universitaria

    Pisa, Tuscany, 56124, Italy

  • Oftalmos

    Capital Federal, C1120AAN, Argentina

  • Onnis Instituto oftalmológico privado

    Córdoba, Argentina

  • Organizacion Medica de Investigacion

    Buenos Aires, C1015ABO, Argentina

  • Ospedale Classificato Equiparato Sacro Cuore - Don Calabria; Dipartimento Oculistica

    Negrar - Verona, Veneto, 37024, Italy

  • Paducah Retinal Center

    Paducah, Kentucky, 42001, United States

  • Palmetto Retina Center

    Florence, South Carolina, 29501, United States

  • Pinderfields Hospital; Clinical Research Team, Rowan House

    Wakefield, WF1 4DG, United Kingdom

  • Pomorski Uniwersytet Medyczny w Szczecinie, Zaklad Patologii Ogolnej PUM"

    Szczecin, 70-111, Poland

  • Rabin Medical Center

    Petah Tikva, 49100, Israel

  • Rambam Health Care Campus

    Haifa, 3109600, Israel

  • Rand Eye

    Deerfield Beach, Florida, 33064, United States

  • Retina Consultants of Houston

    Houston, Texas, 77030, United States

  • Retinal Diagnostic Center

    Campbell, California, 95008, United States

  • Royal Victorian Eye and Ear Hospital

    East Melbourne, Victoria, 3002, Australia

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • SPEKTRUM Osrodek Okulistyki Klinicznej

    Wroclaw, 53-334, Poland

  • Scheie Eye Institute

    Philadelphia, Pennsylvania, 19104, United States

  • Soroka university medical center; Ophtalmology

    Beersheba, 8489501, Israel

  • Specialty Eye Care Medical Center

    Glendale, California, 91203, United States

  • Strathfield Retina Clinic

    Strathfield, New South Wales, 2135, Australia

  • Sunderland Eye Infirmary

    Sunderland, SR2 9HP, United Kingdom

  • Tel Aviv Sourasky MC; Ophtalmology

    Tel Aviv, 6423906, Israel

  • The Lions Eye Institute

    Nedlands, Western Australia, 6009, Australia

  • Universitatsklinikum Leipzig

    Leipzig, 04103, Germany

  • University General Hospital of Heraklion; Department of Ophthalmology

    Heraklion, 711 10, Greece

  • University Hospital Southampton NHS Foundation Trust

    Southhampton, SO16 6YD, United Kingdom

  • University of North Carolina; Kittner Eye Center

    Chapel Hill, North Carolina, 27517, United States

  • Università degli Studi dell'Insubria; Clinica Oculistica

    Varese, Lombardy, 21100, Italy

  • Università degli Studi di Napoli Federico II; Dipartimento di Scienze Oftalmologiche

    Naples, Campania, 80131, Italy

  • Universitätsklinikum Tübingen

    Tübingen, 72076, Germany

  • Vitreous-Retina-Macula

    New York, New York, 10022, United States

  • Wagner Macula & Retina Center

    Norfolk, Virginia, 23451, United States

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