New drug GenSci143 enters first human tests for tough cancers

NCT ID NCT07252414

Recruiting now Disease control Sponsor: Changchun GeneScience Pharmaceutical Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a new drug called GenSci143 in 180 adults with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and check for any signs that the drug can control tumor growth. Participants receive the drug by injection every three weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GenSci143
What this could lead to: If it works, this could point toward a new treatment option for people with advanced solid tumors that have stopped responding to standard therapies.
What could go wrong: This is a very early Phase 1 trial, so the main goal is safety, not effectiveness. It may not shrink tumors or lead to a new treatment, and side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS

Contacts and locations

Locations

Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Hubei Cancer Hospital
RECRUITING

Wuhan, Hubei, 430079, China
Hunan Cancer Hospital
NOT_YET_RECRUITING

Changsha, Hunan, 410013, China
Nanjing Drum Tower Hospital
RECRUITING

Nanjing, Jiangsu, 210000, China
Shandong Cancer Hospital
NOT_YET_RECRUITING

Jinan, Shandong, 250117, China
The First Affiliated Hospital of Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310024, China
The First Affiliated Hospital of Zhengzhou University
RECRUITING

Zhengzhou, Henan, 451191, China
The First Hospital of Shanxi Medical University
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030001, China
Zhongshan Hospital Affiliated to Fudan University
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200032, China

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