Simple blood test could spot transplant rejection before damage is done
NCT ID NCT02423070
First seen Jun 24, 2026 · Last updated Jul 29, 2026 · Updated 6 times
Summary
This study is testing a non-invasive blood test that looks for donor DNA in the blood of heart and lung transplant patients. Higher levels of this DNA may signal early rejection before permanent damage occurs. About 991 participants aged 14 and older will provide blood samples over time to see if the test can predict rejection and improve long-term outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- blood test for donor DNA
- What this could lead to
- If successful, this blood test could help doctors catch organ rejection early, potentially improving survival and quality of life for transplant patients.
- What could go wrong
- This is an observational study, not a treatment trial. The test may not prove accurate enough for routine use, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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INOVA Fairfax Medical
RECRUITINGFalls Church, Virginia, 22042, United States
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Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21218, United States
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MedStar Washington Hospital Center
COMPLETEDWashington D.C., District of Columbia, 20010, United States
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
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University of Maryland
TERMINATEDBaltimore, Maryland, 21228, United States
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Virginia Commonwealth University
ACTIVE_NOT_RECRUITINGRichmond, Virginia, 23284, United States