Simple blood test could spot transplant rejection before damage is done
NCT ID NCT02423070
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing a non-invasive blood test that looks for donor DNA in the blood of heart and lung transplant patients. Higher levels of this DNA may signal early rejection before permanent damage occurs. About 991 participants aged 14 and older will provide blood samples over time to see if the test can predict rejection and improve long-term outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
blood test for donor DNA
What this could lead to
If successful, this blood test could help doctors catch organ rejection early, potentially improving survival and quality of life for transplant patients.
What could go wrong
This is an observational study, not a treatment trial. The test may not prove accurate enough for routine use, and results may not apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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INOVA Fairfax Medical
RECRUITINGFalls Church, Virginia, 22042, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21218, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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MedStar Washington Hospital Center
COMPLETEDWashington D.C., District of Columbia, 20010, United States
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Maryland
TERMINATEDBaltimore, Maryland, 21228, United States
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Virginia Commonwealth University
ACTIVE_NOT_RECRUITINGRichmond, Virginia, 23284, United States