Simple gene test could spot rare gut condition
NCT ID NCT07448753
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether checking two specific genes (ACTG2 and FLNA) in blood or saliva can help diagnose a rare condition called chronic intestinal pseudo-obstruction (CIPO), where the gut acts like it is blocked but no physical blockage exists. Researchers will enroll 20 adults with CIPO who also have weak or absent muscle contractions in the esophagus. The goal is to see how often these gene changes occur in this specific group, which could lead to a simpler, less invasive diagnostic test.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could lead to a simple blood or saliva test to diagnose a rare gut disorder, avoiding more invasive procedures.
What could go wrong
This is a very small, early study (20 people) looking only at two genes. It may not find a clear link, and results may not apply to everyone with the condition.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ospedale Maggiore Policlinico di Milano
Milan, 20122, Italy