Experimental gene therapy aims to revive lung cancer treatment

NCT ID NCT04486833

Recruiting now Disease control Sponsor: Genprex, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental gene therapy called quaratusugene ozeplasmid (Reqorsa) combined with the drug osimertinib (Tagrisso) in people with advanced EGFR-mutant non-small cell lung cancer whose cancer has stopped responding to osimertinib alone. The gene therapy delivers a tumor-suppressing gene to cancer cells. The trial has three parts: a dose-finding phase, an open-label phase, and a randomized phase comparing the combination to chemotherapy. About 158 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: quaratusugene ozeplasmid (Reqorsa) plus osimertinib (Tagrisso)
What this could lead to: If successful, this combination could offer a new treatment option for people with advanced lung cancer whose current medication stops working.
What could go wrong: This is an early-phase trial with a small number of participants, so results may not apply to everyone. The gene therapy is experimental and may cause side effects or not improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG

Contacts and locations

Locations

Carle Cancer Institute
RECRUITING

Urbana, Illinois, 61801, United States
Gabrail Cancer Center Research
RECRUITING

Canton, Ohio, 44718, United States
Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
Maryland Oncology Hematology
RECRUITING

Rockville, Maryland, 20850, United States
Millennium Oncology
TERMINATED

Houston, Texas, 77090, United States
Rocky Mountain Cancer Centers
RECRUITING

Lone Tree, Colorado, 80124, United States
The Valley Hospital - Luckow Pavilion
RECRUITING

Paramus, New Jersey, 07652, United States
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States

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