New gene therapy combo targets Drug-Resistant lung cancer
NCT ID NCT04486833
First seen Nov 01, 2025 · Last updated Apr 24, 2026 · Updated 26 times
Summary
This study tests a new gene therapy (quaratusugene ozeplasmid) combined with the drug osimertinib in people with advanced EGFR-mutant non-small cell lung cancer whose cancer has stopped responding to osimertinib alone. The treatment aims to restore a tumor-suppressing gene to help control the cancer. About 158 adults will take part, and the study will check safety and whether the combination shrinks tumors or delays cancer growth.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Carle Cancer Institute
RECRUITINGUrbana, Illinois, 61801, United States
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Gabrail Cancer Center Research
RECRUITINGCanton, Ohio, 44718, United States
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Markey Cancer Center
RECRUITINGLexington, Kentucky, 40536, United States
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Maryland Oncology Hematology
RECRUITINGRockville, Maryland, 20850, United States
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Millennium Oncology
TERMINATEDHouston, Texas, 77090, United States
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Rocky Mountain Cancer Centers
RECRUITINGLone Tree, Colorado, 80124, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Valley Hospital - Luckow Pavilion
RECRUITINGParamus, New Jersey, 07652, United States
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Valkyrie Clinical Trials
RECRUITINGLos Angeles, California, 90067, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Virginia Cancer Specialists
RECRUITINGFairfax, Virginia, 22031, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Virginia Oncology Associates
RECRUITINGNorfolk, Virginia, 23502, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.