Gene therapy trial offers hope for rare Blindness-Causing eye disease

NCT ID NCT07406854

First seen Feb 13, 2026 · Last updated May 12, 2026 · Updated 12 times

Summary

This study tests a gene therapy called NR082 for Leber's hereditary optic neuropathy (LHON), a rare inherited eye disease that leads to vision loss. About 95 people aged 12 to 75 with a specific gene mutation (ND4) and vision problems lasting 6 months to 10 years will receive a single injection into each eye or a sham procedure. The goal is to see if the treatment safely improves eyesight over 52 weeks.

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Contacts and locations

Locations

  • Beijing Tongren Hospital, Capital Medical University

    Beijing, Beijing Municipality, China

Conditions

Explore the condition pages connected to this study.