Blood filtering paves way for gene therapy in boys with rare muscle disease

NCT ID NCT06597656

Summary

This early-stage study tested a one-time gene therapy for Duchenne muscular dystrophy (DMD) in a very specific group: three boys who already had antibodies that might block the treatment. To try and get around this, doctors first used a blood-filtering procedure called plasmapheresis. The main goals were to see if this approach was safe and if the therapy could successfully deliver a working gene to produce a needed muscle protein.

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Contacts and locations

Locations

  • Nationwide Children's Hospital

    Columbus, Ohio, 43205, United States

  • University of Florida, College of Medicine

    Gainesville, Florida, 32610, United States

  • Washington University School of Medicine in St. Louis

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.