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New antibody drug tested for tough blood cancers – but trial stopped early

NCT ID NCT04824794

Terminated Disease control Sponsor: Genmab Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new experimental drug called GEN3014 (HexaBody-CD38) in people with multiple myeloma and other blood cancers that had returned or become resistant to treatment. The main goal was to check safety and find the right dose. The trial was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

GEN3014 (HexaBody-CD38) and daratumumab

What this could lead to

If successful, this could lead to a new treatment option for people with blood cancers that have returned or stopped responding to other therapies.

What could go wrong

This was a very early (Phase 1/2) trial, so the drug might not work or could have serious side effects. The trial was terminated, meaning it stopped early, so results are limited.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia diffuse large B-cell lymphoma plasma cell myeloma Recurrence refractory plasma cell neoplasm relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA (AML) DIFFUSE LARGE B CELL LYMPHOMA (DLBCL) RELAPSED OR REFRACTORY MULTIPLE MYELOMA (RRMM)

Contacts and locations

Locations

  • ARENSIA Exploratory Medicine LLC

    Tbilisi, Georgia

  • Aalborg Universitet

    Aalborg, Denmark

  • Ahepa University General hospital

    Thessaloniki, Greece

  • Alexandra General Hospital

    Athens, Greece

  • Arensia Exploratory Medicine

    Kyiv, Ukraine

  • Auckland Cancer Trials Centre

    Grafton, New Zealand

  • Beacon Hospital

    Petaling Jaya, Malaysia

  • CHRU de Lille

    Lille, France

  • CHRU de Nantes

    Nantes, France

  • Chonnam National University Hwasun Hospital

    Gwangju, South Korea

  • Christchurch Hospital

    Christchurch, New Zealand

  • Erasmus MC

    Rotterdam, Netherlands

  • Evangelismos Hospital NKUA

    Athens, Greece

  • FNO - Fakultni nemocnice Ostrava

    Poruba, Czechia

  • Fakultni Nemocnice Brno

    Brno, Czechia

  • Fakultni Nemocnice Hradec Kralove FNHK

    Nový Hradec Králové, Czechia

  • Fakultni Nemocnice Olomouc (FNOL)

    Olomouc, Czechia

  • Gachon University Gil Medical Center

    Seongnam, South Korea

  • Hospital Ampang

    Ampang, Malaysia

  • Hospital Sultanah Aminah

    Johor Bahru, Malaysia

  • Hospital Umum Sarawak

    Kuching, Malaysia

  • Institute of Oncology, ARENSIA Exploratory Medicine

    Chisinau, Moldova

  • John Theurer Cancer Center

    Hackensack, New Jersey, 07601, United States

  • Karolinska Institute

    Huddinge, Sweden

  • Klinika za hematologiju KCUS

    Sarajevo, Bosnia and Herzegovina

  • Maastricht UMC

    Maastricht, Netherlands

  • Makati Medical Center

    Makati City, Philippines

  • Medical college of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • North Shore Hospital

    Takapuna, New Zealand

  • Northern Health

    Epping, Australia

  • Palmerston North Hospital

    Palmerston North, New Zealand

  • Pratia MCM

    Krakow, Poland

  • Pratia Onkologia Katowice

    Katowice, Poland

  • Pusan National University Hospital PNUH

    Pusan, South Korea

  • Royal Prince Alfred Hospital

    Sydney, Australia

  • Samsung Medical Center

    Seoul, South Korea

  • Seoul National University Hospital

    Seoul, South Korea

  • Szabolcs-Szatmar-Bereg County Hospitals and University Hospital, Josa Andras University Hospital

    Nyíregyháza, Hungary

  • The Alfred Hospital

    Melbourne, Australia

  • UKC - University Clinical Center Tuzla

    Tuzla, Bosnia and Herzegovina

  • UMC Utrecht

    Utrecht, Netherlands

  • Universitetssjukhuset i Lund

    Lund, Sweden

  • University Centrum Kliniczne

    Gdansk, Poland

  • University Clinic of Hematology

    Skopje, North Macedonia

  • University Clinical Center of the Republic of the Srpska

    Banja Luka, Bosnia and Herzegovina

  • University General Hospital of Patras

    Rio, Greece

  • University Hospital of Salamanca

    Salamanca, Spain

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of Navarra

    Pamplona, Spain

  • Vejle Hospital

    Vejle, Denmark

  • Vseobecna fakultni nemocnice

    New Town, Czechia

  • Wroclaw Medical University

    Wroclaw, Poland