Experimental cancer drug GEN1047 tested in humans – study halted early

NCT ID NCT05180474

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new drug called GEN1047 in people with advanced solid tumors (breast, endometrial, ovarian, or lung cancer) who had no other treatment options. The goal was to check safety, side effects, and how the body processes the drug. The study was terminated early, but the data may still help understand the drug's potential.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm endometrial cancer endometrium neoplasm non-small cell squamous lung carcinoma ovarian cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Antwerp University Hospital

    Edegem, 2650, Belgium

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • CHU Poitiers - Hôpital la Milétrie

    Poitiers, France

  • CHU de Besancon

    Besançon, 25030, France

  • Case Western Reserve University

    Cleveland, Ohio, 44106, United States

  • Centre Léon Bérard

    Lyon, 69008, France

  • Centro Oncologico Clara Campal

    Madrid, 28050, Spain

  • Clinica Universidad de Navarra

    Pamplona, 31008, Spain

  • Erasmus Medisch Centrum

    Rotterdam, 3015CE, Netherlands

  • Fondazione IRCCS San Gerardo dei Tintori

    Monza, 20900, Italy

  • Hospital Clinic de Barcelona

    Barcelona, Spain

  • Hospital Clinico Universitario de Valencia

    Valencia, Spain

  • Hospital Ruber Internacional

    Madrid, 28034, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, 8035, Spain

  • Hospital Universitary Fundacion Jimenez Diaz

    Madrid, 2815, Spain

  • Hôpital Cochin

    Paris, France

  • IEO Istituto Europeo di Oncologia

    Milan, 435, Italy

  • Institut Bergonié

    Bordeaux, France

  • Institut Claudius Regaud

    Toulouse, France

  • Institut Curie

    Paris, 75248, France

  • Institut Gustave Roussy

    Villejuif, 75005, France

  • Institut du Cancer de Montpellier

    Montpellier, 34298, France

  • MD Anderson Cancer Center

    Madrid, 28033, Spain

  • Med-Polonia Sp. z o.o

    Poznan, Poland

  • NEXT Oncology Madrid

    Madrid, Spain

  • Radboudumc

    Nijmegen, 6525GA, Netherlands

  • Rigshospitalet (Copenhagen University Hospital)

    Copenhagen, 2100, Denmark

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203, United States

  • St Bartholomews Hospital

    London, EC1A7BE, United Kingdom

  • The Christie Hospital

    Manchester, M20 4BX, United Kingdom

  • UCLA Department of Medicine Hematology Oncology

    Los Angeles, California, 90024, United States

  • Universitair Ziekenhuis Leuven

    Leuven, 3000, Belgium

  • University College London Hospital

    London, NW1 2BU, United Kingdom

  • University Medical Center Groningen

    Groningen, 9713GZ, Netherlands

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Yale University - Yale Cancer Center

    New Haven, Connecticut, 06520-8028, United States