Experimental CAR t therapy takes aim at stubborn AL amyloidosis
NCT ID NCT07250269
First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 3 times
Summary
This early-phase trial is testing a new treatment called GC012F for people with AL amyloidosis that has come back or not responded to other therapies. GC012F is a type of immunotherapy that uses a patient's own immune cells, modified to attack two specific targets on the abnormal cells causing the disease. The study will enroll 9 adults to check safety and see if the treatment can reduce signs of the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- GC012F (a dual-target CAR T cell therapy that attacks two proteins on cancer cells)
- What this could lead to
- If it works, this could point toward a new treatment option for people with hard-to-treat AL amyloidosis, potentially controlling the disease and improving organ function.
- What could go wrong
- This is a very early Phase 1 trial with only 9 participants, so it's too small to prove effectiveness. CAR T therapy can cause serious side effects like cytokine release syndrome, and the long-term benefits are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Research Site
RECRUITINGBeijing, 100034, China
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Research Site
RECRUITINGBeijing, 100070, China
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Research Site
RECRUITINGBeijing, CN-100730, China
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Research Site
RECRUITINGChangchun, 130021, China
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Research Site
RECRUITINGGuangzhou, 510100, China
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Research Site
NOT_YET_RECRUITINGHangzhou, 310003, China
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Research Site
RECRUITINGSuzhou, 215006, China
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Research Site
RECRUITINGWenzhou, 325000, China
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Research Site
NOT_YET_RECRUITINGWuhan, 430022, China