Will a High-Fat meal change how this drug works? new study investigates
NCT ID NCT07099989
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study tests how taking Zelquistinel with or without a high-fat meal changes the amount of drug in the blood and spinal fluid. Thirty-two healthy adults aged 18 to 59 will receive single doses of 3 mg or 10 mg under both fed and fasted conditions. The goal is to understand the best way to take the drug before moving to patient trials.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Zelquistinel (GATE-251)
- What this could lead to
- If successful, this study will show how food affects the body's absorption of Zelquistinel, guiding future dosing instructions for larger trials.
- What could go wrong
- This is an early Phase 1 study in only 32 healthy volunteers, not patients. Results may not predict effects in people with the target condition.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEALTHY VOLUNTEERS IN FED AND FASTED STATE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dr. Vince Clinical Research
Overland Park, Kansas, 66212, United States