Major cancer trial tests new weapon against aggressive stomach tumors

NCT ID NCT03615326

Summary

This large, completed Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab to the standard first-line treatment (trastuzumab plus chemotherapy) could better control advanced HER2-positive stomach or gastroesophageal junction cancer. It involved 738 participants who had not received prior treatment for their advanced cancer. The main goals were to see if the new combination could help patients live longer and keep the cancer from growing for a longer period compared to the standard treatment alone.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • 900 Hospital of the Joint ( Site 2420)

    Fuzhou, Fujian, 350025, China

  • A.O.U. Universita degli Studi della Campania-Luigi Vanvitelli ( Site 1103)

    Naples, 80131, Italy

  • AUOP Ospedale Santa Chiara ( Site 1100)

    Pisa, Tuscany, 56126, Italy

  • Abdurrahman Yurtaslan Onkoloji Egitim ve Arastirma Hastanesi ( Site 2006)

    Ankara, 06200, Turkey (Türkiye)

  • Adana Sehir Hastanesi ( Site 2002)

    Adana, 01370, Turkey (Türkiye)

  • Aichi Cancer Center Hospital ( Site 2617)

    Nagoya, Aichi-ken, 464-8681, Japan

  • Allegheny General Hospital ( Site 0053)

    Pittsburgh, Pennsylvania, 15212, United States

  • Asan Medical Center ( Site 2702)

    Seoul, 05505, South Korea

  • Asklepios Klinik Altona ( Site 1000)

    Hamburg, 22763, Germany

  • Ataturk Universitesi Tip Fakultesi Hastanesi ( Site 2000)

    Erzurum, 25240, Turkey (Türkiye)

  • Auckland City Hospital ( Site 2300)

    Auckland, 1023, New Zealand

  • Azienda Ospedaliero - Universitaria Policlinico di Modena ( Site 1102)

    Modena, 41124, Italy

  • Beaumont Hospital ( Site 1506)

    Dublin, D09 V2N0, Ireland

  • Beijing Cancer Hospital ( Site 2413)

    Beijing, Beijing Municipality, 100142, China

  • Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 1710)

    Bielsko-Biala, Silesian Voivodeship, 43-300, Poland

  • Beth Israel Deaconess Medical Center ( Site 0070)

    Boston, Massachusetts, 02215, United States

  • Blokhin National Medical Oncology ( Site 1805)

    Moscow, Moscow, 115478, Russia

  • C.H.R.U. de Brest - Hopital Morvan ( Site 0913)

    Brest, Finistere, 29200, France

  • CEPON - Centro de Pesquisas Oncologicas ( Site 0200)

    Florianópolis, Santa Catarina, 88034-000, Brazil

  • CHU Hopital Saint Antoine ( Site 0905)

    Paris, 75012, France

  • CHU de Rouen ( Site 0912)

    Rouen, Ain, 76000, France

  • CIONC - Centro Integrado de Oncologia de Curitiba ( Site 0205)

    Curitiba, Paraná, 80810-050, Brazil

  • CTCA Southwestern ( Site 0060)

    Tulsa, Oklahoma, 74133, United States

  • Cancer Hospital Affiliated to Xinjiang Medical University ( Site 2430)

    Ürümqi, Xinjiang, 830001, China

  • Cancer Treatment Centers of America-Eastern Regional Medical Center ( Site 0025)

    Philadelphia, Pennsylvania, 19124, United States

  • Castle Hill Hospital ( Site 1501)

    Cottingham, East Riding Of Yorkshire, HU16 5JQ, United Kingdom

  • Celan SA ( Site 0504)

    Guatemala City, 01010, Guatemala

  • Centre Leon Berard ( Site 0904)

    Lyon, Rhone, 69008, France

  • Centre Oscar Lambret ( Site 0911)

    Lille, Nord, 59000, France

  • Centro Investigación del Cáncer James Lind ( Site 0300)

    Temuco, Región de la Araucanía, 4780000, Chile

  • Centro Regional de Sub Especialidades Medicas SA ( Site 0502)

    Quetzaltenango, 09001, Guatemala

  • Chaim Sheba Medical Center. ( Site 1607)

    Ramat Gan, 5265601, Israel

  • Charite-Universitaetsmedizin Berlin Campus Virchow-Klinikum ( Site 1026)

    Berlin, 13353, Germany

  • Chelyabinsk Regional Clinical Oncological Dispensary ( Site 1815)

    Chelyabinsk, Chelyabinsk Oblast, 454087, Russia

  • Chiba Cancer Center ( Site 2623)

    Chiba, 260-8717, Japan

  • City Clinical Hosp.4 of DCC ( Site 2102)

    Dnipro, Dnipropetrovsk Oblast, 49102, Ukraine

  • Clinic of National Cancer Institute ( Site 2104)

    Kyiv, Kyivska Oblast, 03022, Ukraine

  • Clinica Universidad Catolica del Maule ( Site 0305)

    Talca, Maule Region, 3460000, Chile

  • Communal non profit enterprise Regional Clinical Oncology Center ( Site 2112)

    Kharkiv, Kharkivs’ka Oblast’, 61070, Ukraine

  • Dana-Farber Cancer Institute [Boston, MA] ( Site 0010)

    Boston, Massachusetts, 02215, United States

  • Dokuz Eylul Universitesi Tip Fakultesi Hastanesi ( Site 2011)

    Izmir, 35340, Turkey (Türkiye)

  • Dolnoslaskie Centrum Onkologii. ( Site 1712)

    Wroclaw, Lower Silesian Voivodeship, 53-413, Poland

  • Duke Cancer Institute ( Site 0042)

    Durham, North Carolina, 27710, United States

  • Edith Wolfson Medical Center ( Site 1605)

    Holon, 5822012, Israel

  • Facharztzentrum Eppendorf ( Site 1025)

    Hamburg, 20249, Germany

  • Fifth Medical Center of CPLA General Hospital ( Site 2415)

    Beijing, Beijing Municipality, 100071, China

  • Fudan University Shanghai Cancer Center ( Site 2424)

    Shanghai, Shanghai Municipality, 200032, China

  • Fujian Provincial Cancer Hospital ( Site 2418)

    Fuzhou, Fujian, 350014, China

  • Fundacion Arturo Lopez Perez FALP ( Site 0302)

    Santiago, Region M. de Santiago, 7500921, Chile

  • Gifu University Hospital ( Site 2621)

    Gifu, 501-1194, Japan

  • Grupo Angeles SA ( Site 0501)

    Guatemala City, 01015, Guatemala

  • Guangdong General Hospital ( Site 2433)

    Guangzhou, Guangdong, 510080, China

  • Gunma Prefectural Cancer Center ( Site 2602)

    Ohta, Gunma, 373-8550, Japan

  • HUS Hopital Hautepierre ( Site 0910)

    Strasbourg, Bas-Rhin, 67098, France

  • Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 2017)

    Ankara, 06100, Turkey (Türkiye)

  • Hadassah Ein Kerem Medical Center ( Site 1604)

    Jerusalem, 9112001, Israel

  • Harbin Medical University Cancer Hospital ( Site 2407)

    Harbin, Heilongjiang, 150081, China

  • Henan Cancer Hospital ( Site 2400)

    Zhengzhou, Henan, 450008, China

  • Hiroshima City Hiroshima Citizens Hospital ( Site 2625)

    Hiroshima, 730-8518, Japan

  • Hopital Jean Minjoz Besancon ( Site 0901)

    Besançon, Doubs, 25030, France

  • Hospital General Universitari Vall d Hebron ( Site 1401)

    Barcelona, 08035, Spain

  • Hospital General Universitario de Elche ( Site 1404)

    Elche, Alicante, 03203, Spain

  • Hospital Germans Trias i Pujol. ICO de Badalona ( Site 1410)

    Badalona, Barcelona, 08916, Spain

  • Hospital Nossa Senhora da Conceicao ( Site 0203)

    Porto Alegre, Rio Grande do Sul, 91350-200, Brazil

  • Hospital Sao Rafael ( Site 0209)

    Salvador, Estado de Bahia, 41253-190, Brazil

  • Hospital Universitario Central de Asturias ( Site 1402)

    Oviedo, Principality of Asturias, 33011, Spain

  • Hospital Universitario Marques de Valdecilla ( Site 1405)

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario Quiron Madrid ( Site 1407)

    Pozuelo de Alarcón, Madrid, 28223, Spain

  • Hospital Universitario Ramon y Cajal ( Site 1400)

    Madrid, 28034, Spain

  • Hospital de Caridade de Ijui ( Site 0202)

    Ijuí, Rio Grande do Sul, 98700 000, Brazil

  • Humanitas Gavazzeni ( Site 1106)

    Bergamo, 24125, Italy

  • Hyogo Cancer Center ( Site 2619)

    Akashi, Hyōgo, 673-8558, Japan

  • IBCC - Instituto Brasileiro de Controle do Cancer ( Site 0204)

    São Paulo, 03102-002, Brazil

  • IEO Istituto Europeo di Oncologia ( Site 1105)

    Milan, 20141, Italy

  • Ibaraki Prefectural Central Hospital ( Site 2611)

    Kasama, Ibaraki, 309-1793, Japan

  • Innere Medizin I, Universitaetsklinikum Tuebingen ( Site 1020)

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Institut Gustave Roussy ( Site 0900)

    Villejuif, Val-de-Marne, 94805, France

  • Institut de Cancerologie de l Ouest Centre Rene Gauducheau ( Site 0902)

    Saint-Herblain, Val-de-Marne, 44805, France

  • Instituto Nacional del Cancer ( Site 0303)

    Santiago, Region M. de Santiago, 8380455, Chile

  • Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0201)

    Rio de Janeiro, 20231-050, Brazil

  • Instituto do Cancer do Ceara ( Site 0208)

    Fortaleza, Ceará, 60430-230, Brazil

  • Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 2001)

    Istanbul, 34098, Turkey (Türkiye)

  • Istituto Oncologico Veneto ( Site 1101)

    Padua, 35128, Italy

  • Jiangsu Cancer Hospital ( Site 2432)

    Nanjing, Jiangsu, 210009, China

  • Kagawa University Hospital ( Site 2604)

    Kita-gun, Kagawa-ken, 761-0793, Japan

  • Kanagawa Cancer Center ( Site 2603)

    Yokohama, Kanagawa, 241-8515, Japan

  • Kansai Medical University Hospital ( Site 2618)

    Hirakata, Osaka, 573-1191, Japan

  • Kindai University Hospital ( Site 2616)

    Sayama, Osaka, 589-8511, Japan

  • Klinikum Bremen Nord ( Site 1017)

    Bremen, 28211, Germany

  • Klinikum Ludwigsburg ( Site 1014)

    Ludwigsburg, Baden-Wurttemberg, Germany

  • Klinikum rechts der Isar der Technischen Universitaet ( Site 1027)

    Munich, Bavaria, 81675, Germany

  • Kobe City Medical Center General Hospital ( Site 2614)

    Kobe, Hyōgo, 650-0047, Japan

  • Kumamoto University Hospital ( Site 2601)

    Kumamoto, 860-8556, Japan

  • Kyiv City Clinical Oncology Centre ( Site 2110)

    Kyiv, 03115, Ukraine

  • Kyorin University Hospital ( Site 2608)

    Mitaka, Tokyo, 181-8611, Japan

  • Leningrad Regional Oncology Center ( Site 1800)

    Saint Petersburg, Sankt-Peterburg, 188663, Russia

  • Levine Cancer Institute ( Site 0015)

    Charlotte, North Carolina, 28204, United States

  • Liverpool Hospital ( Site 2206)

    Liverpool, New South Wales, 2170, Australia

  • Lviv State Oncology Regional Treatment and Diagnostic Center ( Site 2106)

    Lviv, Lviv Oblast, 79031, Ukraine

  • MI Kryviy Rih Center of Dnipropetrovsk Regional Council ( Site 2101)

    Kryviy Rih, Dnipropetrovsk Oblast, 50048, Ukraine

  • MI Odessa Regional Oncological Centre ( Site 2108)

    Odesa, Odesa Oblast, 65055, Ukraine

  • MI Precarpathian Clinical Oncology Center ( Site 2105)

    Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine

  • Malatya Inonu Universitesi Tip Fakultesi Hastanesi ( Site 2009)

    Malatya, 44280, Turkey (Türkiye)

  • Manor Hospital Walsall England ( Site 1515)

    Walsall, WS2 9PS, United Kingdom

  • Medi-K Cayala ( Site 0505)

    Guatemala City, 01016, Guatemala

  • Medical Center Asklepion LLC ( Site 2115)

    Khodosovka, Kyivska Oblast, 08173, Ukraine

  • Medical Centre LLC Oncolife ( Site 2103)

    Zaporizhzhya, Zaporizhzhia Oblast, 69104, Ukraine

  • Medical University REAVIZ ( Site 1816)

    Samara, Samara Oblast, 443011, Russia

  • Medical and Diagnostic Centre LLC Dobryi Prognoz ( Site 2114)

    Kyiv, Kyivska Oblast, 03126, Ukraine

  • Medizinische Hochschule Hannover ( Site 1019)

    Hanover, Lower Saxony, 30625, Germany

  • Meir Medical Center ( Site 1609)

    Kfar Saba, 4428132, Israel

  • Memorial Sloan Kettering Cancer Center- Monmouth ( Site 0071)

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan-Kettering Cancer Center ( Site 0017)

    New York, New York, 10065, United States

  • Memorial Sloan-Kettering Cancer Center at West Harrison ( Site 0065)

    Harrison, New York, 10604, United States

  • Midwestern Regional Medical Center, Inc. ( Site 0059)

    Zion, Illinois, 60099, United States

  • Minnesota Oncology Hematology, PA ( Site 8001)

    Minneapolis, Minnesota, 55404, United States

  • Monash Health ( Site 2202)

    Clayton, Victoria, 3168, Australia

  • Mount Vernon Cancer Centre ( Site 1507)

    Northwood, HA6 2RN, United Kingdom

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • National Cancer Center Hospital ( Site 2612)

    Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East ( Site 2605)

    Kashiwa, Chiba, 277-8577, Japan

  • National Hospital Organization - Osaka National Hospital - Institute For Clinical Research ( Site 26

    Osaka, 540-0006, Japan

  • National Hospital Organization Kyushu Cancer Center ( Site 2609)

    Fukuoka, 811-1395, Japan

  • National Hospital Organization Shikoku Cancer Center ( Site 2615)

    Matsuyama, Ehime, 791-0280, Japan

  • Niigata Cancer Center Hospital ( Site 2622)

    Niigata, 951-8566, Japan

  • Ninewells Hospital and Medical School ( Site 1504)

    Dundee, Dundee City, DD1 9SY, United Kingdom

  • Nucare Center ( Site 0506)

    Guatemala City, 01015, Guatemala

  • Oncology & Hematology Assoc. SW Virginia, Inc., DBA Blue Ridge Cancer Care ( Site 8000)

    Roanoke, Virginia, 24014, United States

  • Oncomedica ( Site 0500)

    Guatemala City, 01010, Guatemala

  • Osaka General Medical Center ( Site 2624)

    Osaka, 558-8558, Japan

  • Osaka International Cancer Institute ( Site 2613)

    Osaka, 541-8567, Japan

  • Osaka University Hospital ( Site 2600)

    Suita, Osaka, 565-0871, Japan

  • Osaki Citizen Hospital ( Site 2626)

    Ōsaki, Miyagi, 989-6183, Japan

  • Ospedale Civile Spirito Santo ( Site 1104)

    Pescara, 65100, Italy

  • Pacific Cancer Care ( Site 0063)

    Monterey, California, 93940, United States

  • Peking Union Medical College Hospital ( Site 2419)

    Beijing, Beijing Municipality, 100032, China

  • Podolsky City Clinical Hospital ( Site 1817)

    Podolsk, Moscow Oblast, 142110, Russia

  • Pontificia Universidad Catolica de Chile ( Site 0301)

    Santiago, Region M. de Santiago, 7620002, Chile

  • Przychodnia Lekarska Komed ( Site 1716)

    Konin, Greater Poland Voivodeship, 62-500, Poland

  • Rabin Medical Center ( Site 1602)

    Petah Tikva, 4941492, Israel

  • Rambam Health Care Campus ( Site 1606)

    Haifa, 3109601, Israel

  • Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1807)

    Ufa, Baskortostan, Respublika, 450054, Russia

  • Royal Hospital in Derby ( Site 1514)

    Derby, Derbyshire, DE22 3NE, United Kingdom

  • Royal Marsden Hospital ( Site 1510)

    Sutton, Surrey, SM2 5PT, United Kingdom

  • Royal Marsden NHS Foundation Trust ( Site 1512)

    London, SW3 6JJ, United Kingdom

  • SLK-Kliniken Heilbronn ( Site 1015)

    Heilbronn, Baden-Wurttemberg, 74078, Germany

  • Saint James's Hospital ( Site 1505)

    Dublin, D08NHY1, Ireland

  • Saitama Cancer Center ( Site 2620)

    Kitaadachi-gun, Saitama, 362-0806, Japan

  • Sakarya Universitesi Egitim ve Arastirma Hastanesi ( Site 2012)

    Sakarya, 54290, Turkey (Türkiye)

  • Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie ( Site 1709)

    Lublin, Lublin Voivodeship, 20-080, Poland

  • Samsung Medical Center ( Site 2701)

    Seoul, 06351, South Korea

  • Sanford Hematology Oncology-Sioux Falls SD ( Site 0004)

    Sioux Falls, South Dakota, 57104, United States

  • Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1801)

    Saint Petersburg, Sankt-Peterburg, 197758, Russia

  • Seattle Cancer Care Alliance ( Site 0038)

    Seattle, Washington, 98109, United States

  • Seoul National University Hospital ( Site 2703)

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System ( Site 2700)

    Seoul, 03722, South Korea

  • Shanghai General Hospital ( Site 2404)

    Shanghai, Anhui, 200080, China

  • Shizuoka Cancer Center Hospital and Research Institute ( Site 2607)

    Sunto-gun, Shizuoka, 411-8777, Japan

  • Sir Run Run Shaw Hospital ( Site 2412)

    Hangzhou, Zhejiang, 310016, China

  • Soroka University Medical Center ( Site 1603)

    Beersheba, 8410101, Israel

  • Sourasky Medical Center ( Site 1601)

    Tel Aviv, 6423906, Israel

  • Southeastern Regional Medical Center, Inc. ( Site 0058)

    Newnan, Georgia, 30265, United States

  • Southern Medical Day Care Centre ( Site 2207)

    Wollongong, New South Wales, 2500, Australia

  • St Georges University Hospitals NHS Foundation Trust. ( Site 1500)

    London, London, City of, SW17 0QT, United Kingdom

  • St Petersburg City Clinical Oncology Dispensary ( Site 1812)

    Saint Petersburg, Sankt-Peterburg, 198255, Russia

  • Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 1715)

    Gdynia, Pomeranian Voivodeship, 81-519, Poland

  • Szpital Specjalistyczny w Koscierzynie Sp. z o.o. ( Site 1708)

    Kościerzyna, Pomeranian Voivodeship, 83-400, Poland

  • Tallaght University Hospital ( Site 1513)

    Dublin, D24 NR0A, Ireland

  • The Cancer Institute Hospital of JFCR ( Site 2610)

    Tokyo, 135-8550, Japan

  • The Christie Hospital NHS Foundation Trust ( Site 1503)

    Manchester, M20 4BX, United Kingdom

  • The First Affiliated Hospital of Xiamen University ( Site 2431)

    Xiamen, Fujian, 361003, China

  • The First Affiliated Hospital.Zhejiang University ( Site 2408)

    Hangzhou, Zhejiang, 310003, China

  • The First Hospital Of Jilin University ( Site 2402)

    Changchun, Jilin, 130021, China

  • Tochigi Cancer Center ( Site 2627)

    Utsunomiya, Tochigi, 320-0834, Japan

  • Tokyo Metropolitan Komagome Hospital ( Site 2606)

    Tokyo, 113-8677, Japan

  • Toranomon Hospital ( Site 2628)

    Tokyo, 105-8470, Japan

  • Trakya Universitesi Tip Fakultesi ( Site 2015)

    Edirne, 22030, Turkey (Türkiye)

  • UC Irvine Medical Center/Chao Family Comprehensive Cancer Center ( Site 0050)

    Orange, California, 92868, United States

  • UCLA Hematology/Oncology - Westwood (Building 200 Suite 120) ( Site 0045)

    Los Angeles, California, 90095, United States

  • Universita Magna Graecia di Catanzaro ( Site 1107)

    Catanzaro, 88100, Italy

  • Universitaetsklinikum Carl Gustav Carus der Technischen Univ ( Site 1001)

    Dresden, Saxony, 01307, Germany

  • Universitaetsklinikum Leipzig AOeR ( Site 1007)

    Leipzig, Saxony, 04103, Germany

  • University College London Hospital NHS Foundation Trust ( Site 1508)

    London, London, City of, NW1 2PG, United Kingdom

  • University of Miami Sylvester Comprehensive Cancer Center - Plantation ( Site 0026)

    Miami, Florida, 33136, United States

  • University of Rochester ( Site 0041)

    Rochester, New York, 14642, United States

  • University of Texas MD Anderson Cancer Center ( Site 0001)

    Houston, Texas, 77030, United States

  • Uniwersytecki Szpital Kliniczny im. J. M. Radeckiego we Wroclawiu ( Site 1705)

    Wroclaw, Lower Silesian Voivodeship, 50-556, Poland

  • Washington University School of Medicine ( Site 0040)

    St Louis, Missouri, 63110, United States

  • Westmead Hospital ( Site 2200)

    Westmead, New South Wales, 2145, Australia

  • Xiangya Hospital Central-South University ( Site 2426)

    Changsha, Hunan, 410008, China

  • Zhejiang Cancer Hospital ( Site 2409)

    Hangzhou, Zhejiang, 310022, China

  • Zhongshan Hospital affiliated to Fudan University ( Site 2401)

    Shanghai, Shanghai Municipality, 200032, China

Conditions

Explore the condition pages connected to this study.