New HAE drug garadacimab tested in real life: will it hold up?

NCT ID NCT07001280

Recruiting now Disease control Sponsor: CSL Behring Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 200 people with hereditary angioedema (HAE) who are starting garadacimab in routine medical care. Researchers will track how well the drug prevents swelling attacks, its safety, and its impact on quality of life over 48 months. The goal is to see if results from earlier clinical trials hold true in everyday practice.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: garadacimab
What this could lead to: If successful, this study could confirm that garadacimab works well in everyday life for preventing HAE attacks, supporting its broader use.
What could go wrong: This is an observational study, not a controlled trial, so results may be influenced by other factors. It also relies on patient-reported data, which can be less reliable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

angioedema hereditary angioedema hereditary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEREDITARY ANGIOEDEMAS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Addenbrooke's Hospital
RECRUITING

Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
Asthma and Allergy Wellness Center
RECRUITING

Saint Charles, Illinois, 60175-4827, United States
Barts Health NHS Trust
RECRUITING

London, Greater London, E1 1RD, United Kingdom
Birmingham Heartlands Hospital
RECRUITING

Birmingham, West Midlands, B 9 5SS, United Kingdom
Cardiff & Vale University HB
RECRUITING

Cardiff, South Glamorgan, CF14 4XU, United Kingdom
Charité - Campus Charité Mitte
RECRUITING

Berlin, 10117, Germany

Contact Email: •••••@•••••
Family Allergy and Asthma
NOT_YET_RECRUITING

Louisville, Kentucky, 40217, United States
Frimley Park Hospital
RECRUITING

Frimley, Surrey, GU16 7UJ, United Kingdom
HZRM Haemophilie-Zentrum Rhein Main
ACTIVE_NOT_RECRUITING

Frankfurt am Main, Hesse, 60596, Germany
John Hopkins University
ACTIVE_NOT_RECRUITING

Baltimore, Maryland, 21287, United States
Kepler Universitätsklinikum - Med Campus III.
RECRUITING

Linz, 4021, Austria
Leeds Teaching Hospitals NHS Trust
RECRUITING

Leeds, West Yorkshire, LS9 7TF, United Kingdom
Manchester Royal Infirmary
RECRUITING

Manchester, Greater Manchester, M13 9WL, United Kingdom
Medical Research of Arizona
RECRUITING

Phoenix, Arizona, 85248, United States
Medizinische Hochschule Hannover
ACTIVE_NOT_RECRUITING

Hanover, Lower Saxony, 30625, Germany
Providence Health Care Society
RECRUITING

Vancouver, British Columbia, V6Z 2K5, Canada
Riverside Medical Group, Belleville
RECRUITING

Belleville, New Jersey, 07109, United States
Sirven and Associates
RECRUITING

Miami, Florida, 33183, United States
Universitaetsklinikum Carl Gustav Carus TU Dresden
RECRUITING

Leipzig, Saxony, 01307, Germany
Universitaetsklinikum Schleswig Holstein - Campus Luebeck
RECRUITING

Hamburg, Schleswig-Holstein, 23538, Germany
Universitaetsklinikum Ulm
RECRUITING

Ulm, Baden-Wurttemberg, 89081, Germany
Washington University
ACTIVE_NOT_RECRUITING

St Louis, Missouri, 63141, United States