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Water pill showdown: does adding albumin boost urine output in ICU patients?

NCT ID NCT07417969

Symptom relief Sponsor: Jose J Zaragoza, MD MSc Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares furosemide alone versus furosemide plus albumin in 56 critically ill adults with fluid overload and low urine output. The goal is to see if the combination increases urine production more effectively. Participants receive either furosemide plus a dummy shot or furosemide plus albumin, and urine output is measured after 2 hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
furosemide and albumin
What this could lead to
If it works, this could point toward a better way to help critically ill patients produce more urine and reduce fluid overload.
What could go wrong
This is a small, early-stage trial with only 56 participants, so results may not apply broadly. Adding albumin also carries risks like allergic reactions or fluid shifts.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 56 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ≥18 years * Critically ill patients admitted to the intensive care unit (ICU) * Presence of oliguria defined as urine output \<0.5 mL/kg/hour for at least 6 hours Exclusion Criteria: * Refusal to participate by the patient or legal representative * Patients receiving palliative or end-of-life care * Acute or chronic kidney failure requiring ongoing renal replacement therapy at enrollment * Chronic dialysis dependency * Participation in another interventional clinical trial * Pregnant or lactating women

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Conditions

The condition(s) this trial relates to.

Edema Oliguria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Urine output decreased

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • 76000

    RECRUITING

    Querétaro City, Querétaro, 26089, Mexico

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