New combo aims to stall advanced breast cancer

NCT ID NCT01992952

First seen Jan 10, 2026 · Last updated May 15, 2026 · Updated 14 times

Summary

This study tests whether adding an experimental drug (AZD5363) to standard hormone therapy (fulvestrant) can help control advanced breast cancer in postmenopausal women. About 150 women whose cancer worsened on previous hormone therapy will receive either the combo or a placebo. The goal is to see if the combo delays cancer growth and to find the safest dose.

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Contacts and locations

Locations

  • Blackpool Victoria Hospital

    Blackpool, United Kingdom

  • Calderdale and Huddersfield NHS Foundation Trust

    Huddersfield, United Kingdom

  • Christie Hospital

    Manchester, Greater Manchester, United Kingdom

  • Clatterbridge Cancer Centre

    Bebington, United Kingdom

  • Derriford Hospital

    Plymouth, United Kingdom

  • Glan Clwyd Hospital

    Rhyl, United Kingdom

  • Great Western General Hospital

    Edinburgh, United Kingdom

  • Mount Vernon Cancer Centre

    London, United Kingdom

  • Queen's Hospital

    Romford, United Kingdom

  • Royal Albert and Edward Infirmary -Wrightington

    Wigan, United Kingdom

  • Royal Blackburn Hospital

    Blackburn, United Kingdom

  • Royal Free Hospital

    London, United Kingdom

  • Royal Preston Hospital

    Preston, United Kingdom

  • Royal Stoke University Hospital

    Stoke-on-Trent, United Kingdom

  • Southampton General Hospital

    Southampton, United Kingdom

  • St James's University Hospital

    Leeds, United Kingdom

  • The Ipswich Hospital NHS Trust

    Ipswich, United Kingdom

  • University Hospital of North Durham

    Durham, United Kingdom

  • University Hospitals Morecambe Bay

    Lancaster, United Kingdom

  • Velindre NHS Trust

    Cardiff, Cardiff, United Kingdom

  • Ysbyty Gwynedd

    Bangor, United Kingdom

Conditions

Explore the condition pages connected to this study.