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Can a Heartbeat-Based guide improve fluid balance in brain surgery?

NCT ID NCT07787455

Disease control Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This trial tests whether using pulse pressure variability (PPV) to guide fluid therapy during brain surgery (craniotomy) can reduce the amount of IV fluids given compared to the traditional central venous pressure (CVP) method. The study will enroll 50 adults aged 18-65 who are having craniotomy operations. The goal is to see if PPV-guided fluid management leads to more precise fluid administration, potentially improving patient outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Goal-directed fluid therapy using pulse pressure variability (PPV) compared with central venous pressure (CVP) monitoring
What this could lead to
If PPV-guided fluid therapy proves better, it could lead to more precise fluid management during brain surgery, potentially reducing complications and improving recovery.
What could go wrong
This is a small, early-stage trial (50 patients), so results may not apply broadly. PPV may not be reliable in all patients, and the study may not show a clear advantage over standard CVP monitoring.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

50 people

The number who actually took part.

Started

Jan 2026

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

PT WAS RANDOMLY ALLOACTED TO 2 GROUPS GROUP A : CVP BETWEEN 8-10 CMH2O GROUP B : PPV LESS THAN 13 %

Ages

18 to 65 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA I,II AGE 18-65 Exclusion Criteria: CHRONIC CARDIC ARRHYTHMIA FLASE HIGH CVP ALTERED MYOCARDIAL FUNCTION PERIPHRAL VASCULAR DISEASE SEVER RESPRITORY DISEASE PEREGANACY PATIENT REFUSAL EXCESSIVE BLOOD LOSS OPERATIONS \-

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Volume of fluid

Contacts and locations

Locations

  • Ain Shams University

    Cairo, Egypt