New triple therapy targets tough leukemia in older patients
NCT ID NCT05520567
First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 33 times
Summary
This study tests a combination of three drugs (gilteritinib, venetoclax, and azacitidine) in people newly diagnosed with a fast-growing form of acute myeloid leukemia (AML) that has a specific gene change (FLT3 mutation). Participants are older or have other health issues that prevent them from receiving standard intensive chemotherapy. The goal is to find the best doses and see if the combination can put the leukemia into remission while managing side effects.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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City of Hope Nat'l Medical Center
Duarte, California, 91010, United States
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Johns Hopkins University
Baltimore, Maryland, 21287, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Memorial Cancer Institute
Pembroke Pines, Florida, 33028, United States
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Motefiore-Einstein Center for Cancer Care
The Bronx, New York, 10461, United States
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Novant Health
Winston-Salem, North Carolina, 27103, United States
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Ohio State University
Columbus, Ohio, 43210, United States
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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Robert H. Lurie Comprehensive Cancer Center
Chicago, Illinois, 61612, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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Sarah Cannon Research Institute
Denver, Colorado, 80218, United States
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The Medical College of Wisconsin- Froedtert Hospital
Milwaukee, Wisconsin, 53226, United States
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The University of Texas MD
Houston, Texas, 77030, United States
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Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
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UCLA Medical Center
Los Angeles, California, 90095, United States
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Univ. of California - Irvine
Irvine, California, 92697, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Maryland
Baltimore, Maryland, 21201, United States
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University of Pennsylvania-Abramson CCC-Dept. of Hem Onc
Philadelphia, Pennsylvania, 19104, United States
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Weill Cornell Medical College
New York, New York, 10065, United States
Conditions
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