New drug duo aims to extend life in tough-to-treat head and neck cancer

NCT ID NCT06064877

Recruiting now Disease control Sponsor: AVEO Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Apr 10, 2026 · Last updated May 14, 2026 · Updated 4 times

Summary

This phase 3 study tests whether adding ficlatuzumab to standard cetuximab helps people with recurrent or metastatic HPV-negative head and neck cancer live longer or keep their cancer from growing. About 410 adults will receive either the combination or a placebo plus cetuximab. The goal is to see if the new combo improves survival and delays cancer progression.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

AOU Careggi
RECRUITING

Florence, 51134, Italy
AdventHealth Medical Group Oncology & Hematology at Orlando
RECRUITING

Orlando, Florida, 32804, United States
Ajou University Hospital
RECRUITING

Suwon, 16499, South Korea
Antoni van Leeuwenhoek
WITHDRAWN

Amsterdam, 1066, Netherlands
Assistance Publique Hopitaux de Marseille (APHM)-Hôpital La Timone
RECRUITING

Marseille, 13005, France
Azienda Ospedaliera Universitaria Maggiore Della Carita Novara
RECRUITING

Novara, 28100, Italy
Banner MD Anderson Cancer Center
RECRUITING

Gilbert, Arizona, 85212, United States
CHU Liège
RECRUITING

Liège, 4000, Belgium
CHU Universite Catholique de Louvain
RECRUITING

Namur, B5000, Belgium
Centre Léon Bérard
RECRUITING

Lyon, 69008, France
Centrul radioterapie Amethyst Cluj-Napoca
RECRUITING

Floreşti, 407280, Romania
Centrum Onkologii im. prof. F. Lukaszczyka w Bydgoszczy
RECRUITING

Bydgoszcz, 85-796, Poland
Chang Gung Memorial Hospital - Kaohsiung
RECRUITING

Kaohsiung City, 833401, Taiwan
Chang Gung Memorial Hospital - Linkou
RECRUITING

Taoyuan, 33305, Taiwan
Changhua Christian Hospital
RECRUITING

Changhua, 500, Taiwan
Charite-Universitaetsmedizin Berlin - Campus Virchow-Klinikum (CVK) - Medizinische Klinik mit Schwerpunkt Haematologie, Onkologie und Tumorimmunologie
RECRUITING

Berlin, 12200, Germany
China Medical University Hospital (CMUH)
RECRUITING

Taichung, 40447, Taiwan
City Hospital Nottingham
RECRUITING

Nottingham, NG5 1PB, United Kingdom
Clinique Pasteur - Lanroze- Centre Finistérien de Radiothérapie et d'Oncologie
WITHDRAWN

Brest, 29200, France
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Emory University
RECRUITING

Atlanta, Georgia, 30308, United States
Fakultni Nemocnice Kralovske Vinohrady
RECRUITING

Prague, 13400, Czechia
Fakultni Nemocnice Olomouc
WITHDRAWN

Olomouc, 77900, Czechia
Fakultni nemocnice Brno
RECRUITING

Brno, 60200, Czechia
Fakultni nemocnice Bulovka
RECRUITING

Prague, Czechia
Fondazione IRCCS - Istituto Nazionale Tumori - Oncologia
RECRUITING

Milan, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
WITHDRAWN

Roma, 00168, Italy
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Grupo Hospital de Madrid (HM) - Hospital Universitario Madrid Sanchinarro - Centro Integral Oncologico Clara Campal (CIOCC)
RECRUITING

Madrid, 28051, Spain
Hospital Clinico Universitario de Valencia (CHUV)
RECRUITING

Valencia, Spain
Hospital Quironsalud Malaga
RECRUITING

Málaga, 29004, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Marques de Valdecilla
WITHDRAWN

Santander, Spain
Hospital Universitario Vinalopo
RECRUITING

Alicante, 03293, Spain
Hospital Universitario de Torrejón
RECRUITING

Madrid, Spain
Hospital universitario Jerez
RECRUITING

Cadiz, 11407, Spain
Hôpital Privé des Côtes d'Armor
RECRUITING

Plérin, 22190, France
IRCCS - ICS Maugeri
RECRUITING

Pavia, 27100, Italy
IRCCS Istituto Clinico Humanitas - Cancer center
RECRUITING

Milan, 20089, Italy
IRCCS Istituto Scienze Neurologiche
RECRUITING

Bologna, 40139, Italy
IRCCS Ospedale San Raffaele Milano
RECRUITING

Milan, 20132, Italy
Institut Catala d'Oncologia (ICO) - Hospitalet
RECRUITING

Barcelona, 08908, Spain
Institut Catala d'Oncologia - Hospital Duran i Reynals
RECRUITING

Badalona, 08907, Spain
Institut Curie
RECRUITING

Paris, 75248, France
Institut Gustave Roussy
RECRUITING

Villejuif, 94805, France
Institute for Oncology Vojvodina
RECRUITING

Kamenitz, Serbia
Institute of Oncology and Radiology of Serbia
RECRUITING

Belgrade, Serbia
Istituto Oncologico Veneto
RECRUITING

Padua, 35128, Italy
Josa Andras Oktatokorhaz
RECRUITING

Nyíregyháza, 4400, Hungary
Keimyung University Dongsan Hospital
RECRUITING

Daegu, 42601, South Korea
Korea University Anam Hospital
RECRUITING

Seoul, 02841, South Korea
Ludwig-Maximilians University
RECRUITING

Munich, 81377, Germany
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
MaineHealth Institute for Research
RECRUITING

South Portland, Maine, 04106, United States
Manhattan Eye, Ear & Throat Hospital
RECRUITING

New York, New York, 10065, United States
Mary Bird Perkins Cancer Center
RECRUITING

Baton Rouge, Louisiana, 70809, United States
Masaryk Memorial Cancer Institute
RECRUITING

Brno, 65653, Czechia
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
McGill University Health Centre (MUHC)
RECRUITING

Montreal, Quebec, H4A3J1, Canada
Medical College of Wisconsin - Froedtert Hospital Cancer Center
TERMINATED

Milwaukee, Wisconsin, 53202, United States
Medical University of South Carolina (MUSC)
RECRUITING

Charleston, South Carolina, 29425, United States
Medisprof Cancer Center
RECRUITING

Cluj-Napoca, 400641, Romania
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Montefiore Medical Center
WITHDRAWN

The Bronx, New York, 10461, United States
NHS Grampian - Aberdeen Royal Infirmary
RECRUITING

Aberdeen, AB25 2ZN, United Kingdom
National Cheng-Kung University Hospital
WITHDRAWN

Tainan, 704017, Taiwan
National Research Institute of Oncology
RECRUITING

Gliwice, 44-100, Poland
National Taiwan University Hospital
WITHDRAWN

Taipei, 100, Taiwan
Northwell Health Cancer Institute
RECRUITING

Lake Success, New York, 10042, United States
Ohio State University, James Cancer Hospital and Solove Research Institute
RECRUITING

Columbus, Ohio, 43210, United States
Oncology Consultants
RECRUITING

Houston, Texas, 77030, United States
Orszagos Onkologiai Intezet
NOT_YET_RECRUITING

Budapest, 1122, Hungary
Petz Aladar Country Teaching Hospital
WITHDRAWN

Győr, 9024, Hungary
Princess Alexandra Hospital
RECRUITING

Brisbane, Queensland, 4102, Australia
Princess Margaret Cancer Center - University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Pôle Santé Léonard de Vinci
RECRUITING

Chambray-lès-Tours, 37170, France
Radboud University Medical Center
RECRUITING

Nijmegen, 6525, Netherlands
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Sarah Cannon Research Institute
RECRUITING

London, W1G 6AD, United Kingdom
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Siteman Cancer Center - Washington University
RECRUITING

St Louis, Missouri, 63110, United States
St George Hospital
RECRUITING

Kogarah, New South Wales, 2217, Australia
St. John of God Murdoch Hospital
RECRUITING

Murdoch, Western Australia, 6150, Australia
St. Vincent's Hospital
RECRUITING

Sydney, New South Wales, 2010, Australia
Szent Lázár Megyei Kórház
WITHDRAWN

Salgótarján, 3100, Hungary
Taipei Veterans General Hospital
RECRUITING

Taipei, 112201, Taiwan
The Catholic University of Korea, Eunpyeong St. Mary's Hospital
RECRUITING

Seoul, 03312, South Korea
The George Washington University
RECRUITING

Washington D.C., District of Columbia, 20052-0042, United States
The Ottawa Hospital Cancer Centre
WITHDRAWN

Ottawa, Ontario, K1H 8L6, Canada
The Royal Marden Hospital, Surrey
RECRUITING

Sutton, SM2 5PT, United Kingdom
The Royal Marsden NHS Foundation Trust
RECRUITING

London, SW3 6JJ, United Kingdom
The University of Arizona Cancer Center
RECRUITING

Tucson, Arizona, 85719, United States
Tom Baker Cancer Centre (Alberta Health Services)
RECRUITING

Calgary, Alberta, T3N 4N1, Canada
Torbay Hospital
WITHDRAWN

Torquay, TQ2 7AA, United Kingdom
UNIVERSITÄTSKLINIKUM FREIBURG, Klinik für Innere Medizin I, Schwerpunkt Hämatologie, Onkologie und Stammzelltransplantation
RECRUITING

Freiburg im Breisgau, 79106, Germany
UOMI Cancer Center-Clinica Tres Torres
RECRUITING

Barcelona, 08017, Spain
Universita degli Studi di Pavia - Fondazione IRCCS Policlinico San Matteo
RECRUITING

Pavia, 27100, Italy
University Clinical Center Kragujevac
RECRUITING

Kragujevac, Serbia
University Hospital
WITHDRAWN

Panagyurishte, 4500, Bulgaria
University of California Los Angeles
RECRUITING

Los Angeles, California, 90024, United States
University of Cincinnati - UC Health Barrett Cancer Center
WITHDRAWN

Cincinnati, Ohio, 45219, United States
University of Illinois Cancer Center
RECRUITING

Chicago, Illinois, 60612, United States
University of Kansas Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
University of Pecs - Oncology
RECRUITING

Pécs, 7624, Hungary
University of Pittsburgh Medical Center - Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
VCU Massey Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Vall d'Hebron Institut d'Oncologia (VHIO)
RECRUITING

Barcelona, Spain
Vitaz-Sint-Niklaas Moerland
RECRUITING

Sint-Niklaas, 9100, Belgium
Yale School of Medicine - Smilow Cancer Hospital
RECRUITING

New Haven, Connecticut, 06511, United States

Conditions

Explore the condition pages connected to this study.

METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA RECURRENT HEAD AND NECK SQUAMOUS CELL CARCINOMA