New liposome chemo shows promise for tough cancers

NCT ID NCT04047251

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 30 times

Summary

This early-phase study tests a new form of the chemotherapy drug topotecan, wrapped in a liposome (a tiny fat bubble), to see if it is safe and tolerable for people with advanced solid tumors that have not responded to standard treatments. The study includes cancers like ovarian, cervical, sarcoma, and neuroendocrine tumors including Merkel cell carcinoma. About 96 adults will take part to find the best dose and check for side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Dana Farber Cancer Institute (DFCI)

    Boston, Massachusetts, 02215, United States

  • HonorHealth

    Scottsdale, Arizona, 85258, United States

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Ohio State University Wexner Medical Center

    Columbus, Ohio, 43221, United States

  • Sarah Cannon Research Institute at HealthONE

    Denver, Colorado, 80218, United States

  • University of Wisconsin Clinical Science Center

    Madison, Wisconsin, 53792, United States

Conditions

Explore the condition pages connected to this study.