Could a hot flash drug also protect your heart and memory?

NCT ID NCT07606664

Not yet recruiting Symptom relief Sponsor: Rebecca Thurston Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether fezolinetant, a drug for menopausal hot flashes and night sweats, also improves blood vessel function and memory. About 220 women aged 40–65 with moderate to severe symptoms will take either fezolinetant or a placebo daily for 12 weeks. Researchers will measure changes in artery health and cognitive performance to see if the drug offers benefits beyond symptom relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fezolinetant
What this could lead to: If it works, this could show that fezolinetant not only eases hot flashes but also protects blood vessels and memory during menopause.
What could go wrong: This is a Phase 3 trial, but it's still early to know if fezolinetant improves heart or brain health. The study is small and results may not apply to all women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hot Flashes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENOPAUSE HOT FLASHES

Contacts and locations

Locations

University of Illinois, Chicago

Chicago, Illinois, 60612, United States
University of Pittsburgh

Pittsburgh, Pennsylvania, 15260, United States

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