Pill vs. IV: Head-to-Head race to slow debilitating MS

NCT ID NCT04544449

Summary

This large, late-stage study is testing whether a new daily oral medication, fenebrutinib, can slow the worsening of disability in adults with primary progressive multiple sclerosis (PPMS). It directly compares fenebrutinib against an existing intravenous (IV) treatment, ocrelizumab, to see which is more effective. Nearly 1,000 participants worldwide are randomly assigned to receive either the pill (with a placebo IV) or the IV drug (with a placebo pill), with neither the patients nor doctors knowing which treatment is given.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • "Neurofocus" LLC

    Lviv, 79029, Ukraine

  • 401 Military Hospital of Athens

    Athens, 11525, Greece

  • A.O.U. di Parma

    Parma, Emilia-Romagna, 43126, Italy

  • A.R.N.A.S. Civico Di Cristina Benfratelli

    Palermo, Sicily, 90127, Italy

  • AHEPA Univ. General Hospital of Thessaloniki

    Thessaloniki, 54636, Greece

  • AOU Seconda Università degli Studi

    Naples, Campania, 80138, Italy

  • Aarhus Universitetshospital

    Aarhus N, 8200, Denmark

  • Alabama Neurology Associates

    Homewood, Alabama, 35209, United States

  • Ams of Ukraine

    Kharkiv, Kharkiv Governorate, 61068, Ukraine

  • Atrium Health Neurosciences Institute ? Charlotte

    Charlotte, North Carolina, 28204, United States

  • Austin Hospital

    Heidelberg, Victoria, 3084, Australia

  • Barnabas Health Ambulatory Care Center

    Livingston, New Jersey, 07039, United States

  • Baskent Universitesi Ankara Hastanesi

    Çankaya, 06490, Turkey (Türkiye)

  • Box Hill Hospital

    Box Hill, Victoria, 3128, Australia

  • Brain and Mind Research Institute

    Camperdown, New South Wales, 2050, Australia

  • Budapesti Jahn Ferenc Dél-pesti Kórház és Rendel?intézet

    Budapest, 1204, Hungary

  • CHRU de Montpellier, Hopital Gui de Chauliac

    Montpellier, 34295, France

  • CNPE City Clinical Hospital #3 of Chernivtsi City Council

    Chernivtsi, Chernihiv Governorate, 58022, Ukraine

  • Care Clinic

    Katowice, 40-568, Poland

  • CeCim Biocinetic

    Santiago, 8331143, Chile

  • Center of Cardiology and Neurology

    Kirov, 610007, Russia

  • Centro de Especialidades Neurológicas y Rehabilitación - CENyR

    Buenos Aires, C1424, Argentina

  • Centro de Investigaciones Médicas Tucuman

    San Miguel, T4000AXL, Argentina

  • Centro de Pesquisas Clinicas

    São Paulo, São Paulo, 01228-200, Brazil

  • Centrum Medyczne "MEDYK"

    Rzeszów, 35-055, Poland

  • Centrum Medyczne NeuroProtect

    Warsaw, 01-684, Poland

  • Centrum Neurologii Krzysztof Selmaj

    Lodz, 90-324, Poland

  • Charing Cross Hospital

    London, W6 8RF, United Kingdom

  • Charite - Universitatsmedizin Berlin

    Berlin, 10117, Germany

  • City Clinical Hospital #24

    Moskva, Moscow Oblast, 127015, Russia

  • City Hospital #40 of Resort Administrative District

    Saint Petersburg, Sankt-Peterburg, 197706, Russia

  • Cleveland Clinic Lou Ruvo

    Las Vegas, Nevada, 89106, United States

  • Clinexpert Kft.

    Budapest, 1033, Hungary

  • Clinica Alemana

    Vitacura, 0, Chile

  • Clinica Internacional

    Lima, 15001, Peru

  • Clinica Neurologica

    Joinville, Santa Catarina, 89201-165, Brazil

  • Clinical Research Institute

    Tialnepantla, Mexico, 54055, Mexico

  • Clinique NeuroOutaouais

    Gatineau, Quebec, J8Y 1W2, Canada

  • Clinstile S.A de C.V.

    Mexico City, Mexico CITY (federal District), 06700, Mexico

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Complejo Hospitalario Universitario A Coruña (CHUAC)

    A Coruña, LA Coruna, 15006, Spain

  • Dent Neurological Institute

    Amherst, New York, 14226, United States

  • Deutsche Klinik für Diagnostik

    Wiesbaden, 65191, Germany

  • Dragonfly Research, LLC

    Wellesley, Massachusetts, 02481, United States

  • Evergreen MS Center

    Kirkland, Washington, 98034, United States

  • FSBHI Siberian Clinical Center of the Federal Medical and Biological Agency

    Krasnoyarsk, Krasnoyarsk Krai, 660037, Russia

  • Federal center of brain research and neurotechnologies

    Moskva, Moscow Oblast, 117997, Russia

  • Focus CECIC

    Buenos Aires, Argentina

  • Fraser Health Authority - Fraser Health Multiple Sclerosis

    Burnaby, British Columbia, V5G 2X6, Canada

  • Fullerton Neurology and Headache Center

    Fullerton, California, 92835, United States

  • Fundacion Clinica Valle del Lili

    Cali, Colombia

  • Fundacion Rosarina de Neurorehabilitacion

    Rosario, 2000, Argentina

  • Georgetown University Medical Center

    Washington D.C., District of Columbia, 20007, United States

  • Groupe Hospitalier Pellegrin

    Bordeaux, 33076, France

  • Grupo Médico Camino S.C.

    México, Mexico CITY (federal District), 03600, Mexico

  • Hacettepe University Medical Faculty

    Ankara, 06100, Turkey (Türkiye)

  • Hackensack U Med Ctr

    Hackensack, New Jersey, 07601, United States

  • Holy Name Hospital

    Teaneck, New Jersey, 07666, United States

  • Hope Neurology

    Knoxville, Tennessee, 37922, United States

  • Hopital Guillaume Et Rene Laennec

    Nantes, 44805, France

  • Hopital Pierre Wertheimer

    Bron, 69677, France

  • Hopitaux Universitaires de Strasbourg

    Strasbourg, 67091, France

  • Hospital Alvaro Cunqueiro

    Vigo, Pontevedra, 36213, Spain

  • Hospital Eginition

    Athens, 115 28, Greece

  • Hospital Geral de Santo Antonio

    Porto, 4099-001, Portugal

  • Hospital IV Alberto Sabogal Sologuren

    Bellavista, Callao 2, Peru

  • Hospital Juarez de Mexico

    Mexico City, Mexico CITY (federal District), 07760, Mexico

  • Hospital Puerta del Mar

    Cadiz, 11009, Spain

  • Hospital Quiron de Madrid

    Pozuelo de Alarcón, Madrid, 28223, Spain

  • Hospital Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Regional Universitario de Malaga ? Hospital General

    Málaga, 29010, Spain

  • Hospital Santo Antonio dos Capuchos

    Lisbon, 1169-050, Portugal

  • Hospital Universitari Arnau de Vilanova de Lleida

    Lleida, Lerida, 25198, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario Gaffree e Guinle

    Rio de Janeiro, 20270-004, Brazil

  • Hospital Universitario Virgen Macarena

    Seville, 41009, Spain

  • Hospital de Braga

    Braga, 4710-243, Portugal

  • Hospital de Santa Maria

    Lisbon, 1649-035, Portugal

  • Hospital de Sao Joao

    Porto, 4200-319, Portugal

  • Hôpital Pasteur

    Nice, 06002, France

  • IMV Pesquisa Neurológica

    Porto Alegre, Rio Grande do Sul, 90620-130, Brazil

  • IRCCS Istituto Neurologico Neuromed

    Pozzilli, Molise, 86077, Italy

  • IRCCS Ospedale San Raffaele

    Milan, Lombardy, 20132, Italy

  • Inselspital Bern Medizin Neurologie

    Bern, 3010, Switzerland

  • Instituto Nacional de Ciencias Neurológicas - Hospital Mogrovejo

    Lima, Lima 01, Peru

  • Instituto Neurologico de Colombia INDEC

    Medellín, Colombia

  • Instituto Reumatológico Strusberg

    Córdoba, X5000EDC, Argentina

  • Instituto de Neurologia de Curitiba

    Curitiba, Paraná, 81210-310, Brazil

  • Irccs A.O.U.San Martino Ist

    Genoa, Liguria, 16132, Italy

  • Istanbul Universitesi - Cerrahpasa Cerrahpasa Tip Fakultesi

    Istanbul, 34098, Turkey (Türkiye)

  • Jersey Shore University Medical Centre

    Neptune City, New Jersey, 07753, United States

  • John Hunter Hospital

    New Lambton, New South Wales, 2305, Australia

  • Johns Hopkins University School Of Medicine

    Baltimore, Maryland, 21287, United States

  • Josephson Wallack Munshower Neurology PC

    Indianapolis, Indiana, 46256, United States

  • Karadeniz Tecnical Uni. Med. Fac.

    Trabzon, 61080, Turkey (Türkiye)

  • Kepler Universitätsklinikum GmbH - Neuromed Campus

    Linz, 4020, Austria

  • Klinikum rechts der Isar der TU Muenchen

    München, 81675, Germany

  • Kocaeli University Hospital

    Kocaeli, 41380, Turkey (Türkiye)

  • Krasnoyarsk State Medical Academy

    Krasnoyarsk, Krasnoyarsk Krai, 660022, Russia

  • Liverpool Hospital

    Liverpool, New South Wales, 2170, Australia

  • London Health Sciences Centre Uni Campus

    London, Ontario, N6A 5A5, Canada

  • Lviv Regional Clinical Hospital

    Lviv, KIEV Governorate, 79010, Ukraine

  • MEDBUD

    Kyiv, KIEV Governorate, 03037, Ukraine

  • Markhot Ferenc Oktatokorhaz és Rendelointezet

    Eger, 3300, Hungary

  • Med Polonia

    Późna, 60-693, Poland

  • Medical Centre of PE First Private Clinic

    Zhytomyr, Crimean Regional Governmenta, 10008, Ukraine

  • Medical Clinical Research Center of Medical Center LLC Health Clinic

    Vinnytsia, 21009, Ukraine

  • Medical College of Wisconsin, Inc.

    Milwaukee, Wisconsin, 53226-3596, United States

  • Medizinische Universität Wien

    Vienna, 1090, Austria

  • Mersin University Medical Faculty

    Mersin, 33079, Turkey (Türkiye)

  • Mexico Centre for Clinical Research

    Mexico City, Mexico CITY (federal District), 03100, Mexico

  • Miami Valley Hospital South

    Centerville, Ohio, 45459, United States

  • Minneapolis Clinic of Neurology

    Golden Valley, Minnesota, 55422, United States

  • Montreal Neurological Institute and Hospital

    Montreal, Quebec, H3A 2B4, Canada

  • Morriston Hospital

    Swansea, SA6 6NL, United Kingdom

  • Multiprofile Hospital for Active Treatment of Neurology and Psychiatry Sv. Naum EAD

    Sofia, 1113, Bulgaria

  • Municipal Institution Zaporizhzhia Regional Clinical Hospital of Zaporizhzhia Regional Council

    Zaporizhzhia, Kharkiv Governorate, 69600, Ukraine

  • NEURO-CARE Sp. z o.o. Sp. Komandytowa

    Katowice, 40-749, Poland

  • National Center of Social Significant Disease

    Saint Petersburg, Sankt-Peterburg, 197110, Russia

  • Neurocentrum Bydgoszcz sp. z o.o

    Bydgoszcz, 85-796, Poland

  • Neurological Services of Orlando

    Orlando, Florida, 32806, United States

  • Neurology Associates PA

    Maitland, Florida, 32751, United States

  • Neurology Clinic PC

    Cordova, Tennessee, 38018, United States

  • Nmedis sp. z o.o.

    Rzeszów, 35-323, Poland

  • Nottingham University Hospitals NHS Trust

    Nottingham, NG7 2UH, United Kingdom

  • Núcleo de Pesquisa do Rio Grande do Sul

    Porto Alegre, Rio Grande do Sul, 90430-001, Brazil

  • Odesa Regional Clinical Hospital

    Odesa, 65117, Ukraine

  • OhioHealth Riverside Methodist Hospital

    Columbus, Ohio, 43214, United States

  • Ondokuz Mayis Univ. Med. Fac.

    Samsun, 55139, Turkey (Türkiye)

  • Organizacion Sanitas Internacional

    Bogotá, Colombia

  • Ospedale Civile di Montichiari

    Montichiari, Lombardy, 25018, Italy

  • Palo Alto Medical Foundation Research Center

    Sunnyvale, California, 94086, United States

  • Pest Megyei Flor Ferenc Korhaz

    Kistarcsa, 2143, Hungary

  • Policlinico Tor Vergata Dip. Neuroscienze-Clinica Neurologica-UOSD Sclerosi Multipla

    Rome, Lazio, 00133, Italy

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Providence Brain and Spine Institute

    Portland, Oregon, 97225, United States

  • Queen Elizabeth University Hospital

    Glasgow, G51 4TF, United Kingdom

  • Raleigh Neurology Associates

    Raleigh, North Carolina, 27607-6520, United States

  • Rambam Medical Center

    Haifa, 3109601, Israel

  • Recherche Sepmus Inc.

    Greenfield Park, Quebec, J4V 2J2, Canada

  • Regional Clinical Hospital

    Ivano-Frankivsk, 76008, Ukraine

  • Regional Multiple Sclerosis Centre b/o CC ECM Neftyanik

    Tyumen, Tyumen Oblast, 625048, Russia

  • Rigshospitalet

    Glostrup Municipality, 2600, Denmark

  • Royal Melbourne Hospital

    Parkville, Victoria, 3050, Australia

  • Rutgers New Jersey Medical School

    Newark, New Jersey, 07103, United States

  • S-Medicon Egeszsegugyi Szolgaltato Kft.

    Budapest, 1044, Hungary

  • SPSK nr 1

    Zabrze, 41-800, Poland

  • SUNY Upstate Medical University

    Syracuse, New York, 13210, United States

  • Salutem Medical Center

    Vinnytsia, KIEV Governorate, 21009, Ukraine

  • San Juan MS Center

    Guaynabo, 968, Puerto Rico

  • Sancaktepe Training and Research Hospital

    Istanbul, 34785, Turkey (Türkiye)

  • Santa Casa de Misericordia

    Belo Horizonte, Minas Gerais, 30150-221, Brazil

  • Selcuk University Medical Faculty

    Istanbul, 42131, Turkey (Türkiye)

  • Separated structural unit ?University hospital? of Dnipro State Medical University

    Dnipro, Tavria Okruha, Ukraine

  • St. Michael's Hospital

    Toronto, Ontario, M5B-1W8, Canada

  • State Novosibirsk Regional Clinical Hospital

    Novosibirsk, 630087, Russia

  • Stony Brook University Medical Center

    Stony Brook, New York, 11794, United States

  • Studienzentrum Dr. Bischof GmbH

    Böblingen, 71034, Germany

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N 3M5, Canada

  • Sutter East Bay Medical Foundation

    Berkeley, California, 94705, United States

  • Sverdlovsk Regional Clinical Hospital 1

    Yekaterinburg, Sverdlovsk Oblast, 620102, Russia

  • Swedish Medical Center

    Seattle, Washington, 98122, United States

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 6423906, Israel

  • Texas Institute for Neurological Disorders

    Sherman, Texas, 75092, United States

  • The Chaim Sheba Medical Center

    Ramat Gan, 5262100, Israel

  • The Ottawa Hospital - General Campus

    Ottawa, Ontario, K1H 8L6, Canada

  • UC Health, LLC.

    Cincinnati, Ohio, 45267, United States

  • UMHAT Dr. Georgi Stranski

    Pleven, 5800, Bulgaria

  • Uni of Texas Health Science Center At Houston

    Houston, Texas, 77030, United States

  • Universitaetsklinikum Tuebingen

    Tübingen, 72076, Germany

  • University Clinic of Neurology

    Skopje, 1000, North Macedonia

  • University of Alberta Hospital

    Edmonton, Alberta, T6G 1Z1, Canada

  • University of British Columbia

    Vancouver, British Columbia, V6T 1Z3, Canada

  • University of Colorado Denver

    Aurora, Colorado, 80045, United States

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • University of South Florida

    Tampa, Florida, 33612, United States

  • Universitätsklinikum "Carl Gustav Carus", Zentrum für Klinische Neurowissenschaften

    Dresden, 01307, Germany

  • Universitätsklinikum Freiburg, Klinik für Neurologie und Neurophysiologie

    Freiburg im Breisgau, 79106, Germany

  • Universitätsspital Basel

    Basel, 4031, Switzerland

  • Van Yuzuncu Yil University Hospital

    Van, 65080, Turkey (Türkiye)

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Vertebronevrologiya LLC

    Kazan', Tatarstan Republic, 420047, Russia

  • Volyn Regional Clinical Hospital

    Lutsk, 43024, Ukraine

  • Washington University

    St Louis, Missouri, 63128, United States

  • Wayne State University

    Detroit, Michigan, 48201, United States

  • West Virginia University

    Morgantown, West Virginia, 26506, United States

  • Wro Medica

    Wroc?aw, 51-685, Poland

  • Yale University School Of Medicine

    Fairfield, Connecticut, 06824, United States

Conditions

Explore the condition pages connected to this study.