Pill vs. IV: Head-to-Head race to slow debilitating MS
NCT ID NCT04544449
Summary
This large, late-stage study is testing whether a new daily oral medication, fenebrutinib, can slow the worsening of disability in adults with primary progressive multiple sclerosis (PPMS). It directly compares fenebrutinib against an existing intravenous (IV) treatment, ocrelizumab, to see which is more effective. Nearly 1,000 participants worldwide are randomly assigned to receive either the pill (with a placebo IV) or the IV drug (with a placebo pill), with neither the patients nor doctors knowing which treatment is given.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
"Neurofocus" LLC
Lviv, 79029, Ukraine
-
401 Military Hospital of Athens
Athens, 11525, Greece
-
A.O.U. di Parma
Parma, Emilia-Romagna, 43126, Italy
-
A.R.N.A.S. Civico Di Cristina Benfratelli
Palermo, Sicily, 90127, Italy
-
AHEPA Univ. General Hospital of Thessaloniki
Thessaloniki, 54636, Greece
-
AOU Seconda Università degli Studi
Naples, Campania, 80138, Italy
-
Aarhus Universitetshospital
Aarhus N, 8200, Denmark
-
Alabama Neurology Associates
Homewood, Alabama, 35209, United States
-
Ams of Ukraine
Kharkiv, Kharkiv Governorate, 61068, Ukraine
-
Atrium Health Neurosciences Institute ? Charlotte
Charlotte, North Carolina, 28204, United States
-
Austin Hospital
Heidelberg, Victoria, 3084, Australia
-
Barnabas Health Ambulatory Care Center
Livingston, New Jersey, 07039, United States
-
Baskent Universitesi Ankara Hastanesi
Çankaya, 06490, Turkey (Türkiye)
-
Box Hill Hospital
Box Hill, Victoria, 3128, Australia
-
Brain and Mind Research Institute
Camperdown, New South Wales, 2050, Australia
-
Budapesti Jahn Ferenc Dél-pesti Kórház és Rendel?intézet
Budapest, 1204, Hungary
-
CHRU de Montpellier, Hopital Gui de Chauliac
Montpellier, 34295, France
-
CNPE City Clinical Hospital #3 of Chernivtsi City Council
Chernivtsi, Chernihiv Governorate, 58022, Ukraine
-
Care Clinic
Katowice, 40-568, Poland
-
CeCim Biocinetic
Santiago, 8331143, Chile
-
Center of Cardiology and Neurology
Kirov, 610007, Russia
-
Centro de Especialidades Neurológicas y Rehabilitación - CENyR
Buenos Aires, C1424, Argentina
-
Centro de Investigaciones Médicas Tucuman
San Miguel, T4000AXL, Argentina
-
Centro de Pesquisas Clinicas
São Paulo, São Paulo, 01228-200, Brazil
-
Centrum Medyczne "MEDYK"
Rzeszów, 35-055, Poland
-
Centrum Medyczne NeuroProtect
Warsaw, 01-684, Poland
-
Centrum Neurologii Krzysztof Selmaj
Lodz, 90-324, Poland
-
Charing Cross Hospital
London, W6 8RF, United Kingdom
-
Charite - Universitatsmedizin Berlin
Berlin, 10117, Germany
-
City Clinical Hospital #24
Moskva, Moscow Oblast, 127015, Russia
-
City Hospital #40 of Resort Administrative District
Saint Petersburg, Sankt-Peterburg, 197706, Russia
-
Cleveland Clinic Lou Ruvo
Las Vegas, Nevada, 89106, United States
-
Clinexpert Kft.
Budapest, 1033, Hungary
-
Clinica Alemana
Vitacura, 0, Chile
-
Clinica Internacional
Lima, 15001, Peru
-
Clinica Neurologica
Joinville, Santa Catarina, 89201-165, Brazil
-
Clinical Research Institute
Tialnepantla, Mexico, 54055, Mexico
-
Clinique NeuroOutaouais
Gatineau, Quebec, J8Y 1W2, Canada
-
Clinstile S.A de C.V.
Mexico City, Mexico CITY (federal District), 06700, Mexico
-
Columbia University Medical Center
New York, New York, 10032, United States
-
Complejo Hospitalario Universitario A Coruña (CHUAC)
A Coruña, LA Coruna, 15006, Spain
-
Dent Neurological Institute
Amherst, New York, 14226, United States
-
Deutsche Klinik für Diagnostik
Wiesbaden, 65191, Germany
-
Dragonfly Research, LLC
Wellesley, Massachusetts, 02481, United States
-
Evergreen MS Center
Kirkland, Washington, 98034, United States
-
FSBHI Siberian Clinical Center of the Federal Medical and Biological Agency
Krasnoyarsk, Krasnoyarsk Krai, 660037, Russia
-
Federal center of brain research and neurotechnologies
Moskva, Moscow Oblast, 117997, Russia
-
Focus CECIC
Buenos Aires, Argentina
-
Fraser Health Authority - Fraser Health Multiple Sclerosis
Burnaby, British Columbia, V5G 2X6, Canada
-
Fullerton Neurology and Headache Center
Fullerton, California, 92835, United States
-
Fundacion Clinica Valle del Lili
Cali, Colombia
-
Fundacion Rosarina de Neurorehabilitacion
Rosario, 2000, Argentina
-
Georgetown University Medical Center
Washington D.C., District of Columbia, 20007, United States
-
Groupe Hospitalier Pellegrin
Bordeaux, 33076, France
-
Grupo Médico Camino S.C.
México, Mexico CITY (federal District), 03600, Mexico
-
Hacettepe University Medical Faculty
Ankara, 06100, Turkey (Türkiye)
-
Hackensack U Med Ctr
Hackensack, New Jersey, 07601, United States
-
Holy Name Hospital
Teaneck, New Jersey, 07666, United States
-
Hope Neurology
Knoxville, Tennessee, 37922, United States
-
Hopital Guillaume Et Rene Laennec
Nantes, 44805, France
-
Hopital Pierre Wertheimer
Bron, 69677, France
-
Hopitaux Universitaires de Strasbourg
Strasbourg, 67091, France
-
Hospital Alvaro Cunqueiro
Vigo, Pontevedra, 36213, Spain
-
Hospital Eginition
Athens, 115 28, Greece
-
Hospital Geral de Santo Antonio
Porto, 4099-001, Portugal
-
Hospital IV Alberto Sabogal Sologuren
Bellavista, Callao 2, Peru
-
Hospital Juarez de Mexico
Mexico City, Mexico CITY (federal District), 07760, Mexico
-
Hospital Puerta del Mar
Cadiz, 11009, Spain
-
Hospital Quiron de Madrid
Pozuelo de Alarcón, Madrid, 28223, Spain
-
Hospital Ramon y Cajal
Madrid, 28034, Spain
-
Hospital Regional Universitario de Malaga ? Hospital General
Málaga, 29010, Spain
-
Hospital Santo Antonio dos Capuchos
Lisbon, 1169-050, Portugal
-
Hospital Universitari Arnau de Vilanova de Lleida
Lleida, Lerida, 25198, Spain
-
Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
-
Hospital Universitario Gaffree e Guinle
Rio de Janeiro, 20270-004, Brazil
-
Hospital Universitario Virgen Macarena
Seville, 41009, Spain
-
Hospital de Braga
Braga, 4710-243, Portugal
-
Hospital de Santa Maria
Lisbon, 1649-035, Portugal
-
Hospital de Sao Joao
Porto, 4200-319, Portugal
-
Hôpital Pasteur
Nice, 06002, France
-
IMV Pesquisa Neurológica
Porto Alegre, Rio Grande do Sul, 90620-130, Brazil
-
IRCCS Istituto Neurologico Neuromed
Pozzilli, Molise, 86077, Italy
-
IRCCS Ospedale San Raffaele
Milan, Lombardy, 20132, Italy
-
Inselspital Bern Medizin Neurologie
Bern, 3010, Switzerland
-
Instituto Nacional de Ciencias Neurológicas - Hospital Mogrovejo
Lima, Lima 01, Peru
-
Instituto Neurologico de Colombia INDEC
Medellín, Colombia
-
Instituto Reumatológico Strusberg
Córdoba, X5000EDC, Argentina
-
Instituto de Neurologia de Curitiba
Curitiba, Paraná, 81210-310, Brazil
-
Irccs A.O.U.San Martino Ist
Genoa, Liguria, 16132, Italy
-
Istanbul Universitesi - Cerrahpasa Cerrahpasa Tip Fakultesi
Istanbul, 34098, Turkey (Türkiye)
-
Jersey Shore University Medical Centre
Neptune City, New Jersey, 07753, United States
-
John Hunter Hospital
New Lambton, New South Wales, 2305, Australia
-
Johns Hopkins University School Of Medicine
Baltimore, Maryland, 21287, United States
-
Josephson Wallack Munshower Neurology PC
Indianapolis, Indiana, 46256, United States
-
Karadeniz Tecnical Uni. Med. Fac.
Trabzon, 61080, Turkey (Türkiye)
-
Kepler Universitätsklinikum GmbH - Neuromed Campus
Linz, 4020, Austria
-
Klinikum rechts der Isar der TU Muenchen
München, 81675, Germany
-
Kocaeli University Hospital
Kocaeli, 41380, Turkey (Türkiye)
-
Krasnoyarsk State Medical Academy
Krasnoyarsk, Krasnoyarsk Krai, 660022, Russia
-
Liverpool Hospital
Liverpool, New South Wales, 2170, Australia
-
London Health Sciences Centre Uni Campus
London, Ontario, N6A 5A5, Canada
-
Lviv Regional Clinical Hospital
Lviv, KIEV Governorate, 79010, Ukraine
-
MEDBUD
Kyiv, KIEV Governorate, 03037, Ukraine
-
Markhot Ferenc Oktatokorhaz és Rendelointezet
Eger, 3300, Hungary
-
Med Polonia
Późna, 60-693, Poland
-
Medical Centre of PE First Private Clinic
Zhytomyr, Crimean Regional Governmenta, 10008, Ukraine
-
Medical Clinical Research Center of Medical Center LLC Health Clinic
Vinnytsia, 21009, Ukraine
-
Medical College of Wisconsin, Inc.
Milwaukee, Wisconsin, 53226-3596, United States
-
Medizinische Universität Wien
Vienna, 1090, Austria
-
Mersin University Medical Faculty
Mersin, 33079, Turkey (Türkiye)
-
Mexico Centre for Clinical Research
Mexico City, Mexico CITY (federal District), 03100, Mexico
-
Miami Valley Hospital South
Centerville, Ohio, 45459, United States
-
Minneapolis Clinic of Neurology
Golden Valley, Minnesota, 55422, United States
-
Montreal Neurological Institute and Hospital
Montreal, Quebec, H3A 2B4, Canada
-
Morriston Hospital
Swansea, SA6 6NL, United Kingdom
-
Multiprofile Hospital for Active Treatment of Neurology and Psychiatry Sv. Naum EAD
Sofia, 1113, Bulgaria
-
Municipal Institution Zaporizhzhia Regional Clinical Hospital of Zaporizhzhia Regional Council
Zaporizhzhia, Kharkiv Governorate, 69600, Ukraine
-
NEURO-CARE Sp. z o.o. Sp. Komandytowa
Katowice, 40-749, Poland
-
National Center of Social Significant Disease
Saint Petersburg, Sankt-Peterburg, 197110, Russia
-
Neurocentrum Bydgoszcz sp. z o.o
Bydgoszcz, 85-796, Poland
-
Neurological Services of Orlando
Orlando, Florida, 32806, United States
-
Neurology Associates PA
Maitland, Florida, 32751, United States
-
Neurology Clinic PC
Cordova, Tennessee, 38018, United States
-
Nmedis sp. z o.o.
Rzeszów, 35-323, Poland
-
Nottingham University Hospitals NHS Trust
Nottingham, NG7 2UH, United Kingdom
-
Núcleo de Pesquisa do Rio Grande do Sul
Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
-
Odesa Regional Clinical Hospital
Odesa, 65117, Ukraine
-
OhioHealth Riverside Methodist Hospital
Columbus, Ohio, 43214, United States
-
Ondokuz Mayis Univ. Med. Fac.
Samsun, 55139, Turkey (Türkiye)
-
Organizacion Sanitas Internacional
Bogotá, Colombia
-
Ospedale Civile di Montichiari
Montichiari, Lombardy, 25018, Italy
-
Palo Alto Medical Foundation Research Center
Sunnyvale, California, 94086, United States
-
Pest Megyei Flor Ferenc Korhaz
Kistarcsa, 2143, Hungary
-
Policlinico Tor Vergata Dip. Neuroscienze-Clinica Neurologica-UOSD Sclerosi Multipla
Rome, Lazio, 00133, Italy
-
Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
-
Providence Brain and Spine Institute
Portland, Oregon, 97225, United States
-
Queen Elizabeth University Hospital
Glasgow, G51 4TF, United Kingdom
-
Raleigh Neurology Associates
Raleigh, North Carolina, 27607-6520, United States
-
Rambam Medical Center
Haifa, 3109601, Israel
-
Recherche Sepmus Inc.
Greenfield Park, Quebec, J4V 2J2, Canada
-
Regional Clinical Hospital
Ivano-Frankivsk, 76008, Ukraine
-
Regional Multiple Sclerosis Centre b/o CC ECM Neftyanik
Tyumen, Tyumen Oblast, 625048, Russia
-
Rigshospitalet
Glostrup Municipality, 2600, Denmark
-
Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
-
Rutgers New Jersey Medical School
Newark, New Jersey, 07103, United States
-
S-Medicon Egeszsegugyi Szolgaltato Kft.
Budapest, 1044, Hungary
-
SPSK nr 1
Zabrze, 41-800, Poland
-
SUNY Upstate Medical University
Syracuse, New York, 13210, United States
-
Salutem Medical Center
Vinnytsia, KIEV Governorate, 21009, Ukraine
-
San Juan MS Center
Guaynabo, 968, Puerto Rico
-
Sancaktepe Training and Research Hospital
Istanbul, 34785, Turkey (Türkiye)
-
Santa Casa de Misericordia
Belo Horizonte, Minas Gerais, 30150-221, Brazil
-
Selcuk University Medical Faculty
Istanbul, 42131, Turkey (Türkiye)
-
Separated structural unit ?University hospital? of Dnipro State Medical University
Dnipro, Tavria Okruha, Ukraine
-
St. Michael's Hospital
Toronto, Ontario, M5B-1W8, Canada
-
State Novosibirsk Regional Clinical Hospital
Novosibirsk, 630087, Russia
-
Stony Brook University Medical Center
Stony Brook, New York, 11794, United States
-
Studienzentrum Dr. Bischof GmbH
Böblingen, 71034, Germany
-
Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N 3M5, Canada
-
Sutter East Bay Medical Foundation
Berkeley, California, 94705, United States
-
Sverdlovsk Regional Clinical Hospital 1
Yekaterinburg, Sverdlovsk Oblast, 620102, Russia
-
Swedish Medical Center
Seattle, Washington, 98122, United States
-
Tel Aviv Sourasky Medical Center
Tel Aviv, 6423906, Israel
-
Texas Institute for Neurological Disorders
Sherman, Texas, 75092, United States
-
The Chaim Sheba Medical Center
Ramat Gan, 5262100, Israel
-
The Ottawa Hospital - General Campus
Ottawa, Ontario, K1H 8L6, Canada
-
UC Health, LLC.
Cincinnati, Ohio, 45267, United States
-
UMHAT Dr. Georgi Stranski
Pleven, 5800, Bulgaria
-
Uni of Texas Health Science Center At Houston
Houston, Texas, 77030, United States
-
Universitaetsklinikum Tuebingen
Tübingen, 72076, Germany
-
University Clinic of Neurology
Skopje, 1000, North Macedonia
-
University of Alberta Hospital
Edmonton, Alberta, T6G 1Z1, Canada
-
University of British Columbia
Vancouver, British Columbia, V6T 1Z3, Canada
-
University of Colorado Denver
Aurora, Colorado, 80045, United States
-
University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
-
University of Rochester
Rochester, New York, 14642, United States
-
University of South Florida
Tampa, Florida, 33612, United States
-
Universitätsklinikum "Carl Gustav Carus", Zentrum für Klinische Neurowissenschaften
Dresden, 01307, Germany
-
Universitätsklinikum Freiburg, Klinik für Neurologie und Neurophysiologie
Freiburg im Breisgau, 79106, Germany
-
Universitätsspital Basel
Basel, 4031, Switzerland
-
Van Yuzuncu Yil University Hospital
Van, 65080, Turkey (Türkiye)
-
Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
-
Vertebronevrologiya LLC
Kazan', Tatarstan Republic, 420047, Russia
-
Volyn Regional Clinical Hospital
Lutsk, 43024, Ukraine
-
Washington University
St Louis, Missouri, 63128, United States
-
Wayne State University
Detroit, Michigan, 48201, United States
-
West Virginia University
Morgantown, West Virginia, 26506, United States
-
Wro Medica
Wroc?aw, 51-685, Poland
-
Yale University School Of Medicine
Fairfield, Connecticut, 06824, United States
Conditions
Explore the condition pages connected to this study.