New combo therapy tested for tough blood cancer cases

NCT ID NCT05393674

Summary

This study is testing whether combining two drugs, fedratinib and nivolumab, can help control myelofibrosis, a serious bone marrow cancer, in patients whose disease did not respond well to standard JAK-inhibitor therapy. It will involve about 30 adults with primary or secondary myelofibrosis who still have significant symptoms or disease markers. The main goal is to see if this new combination can shrink the spleen, improve blood counts, reduce symptoms, and help patients live longer without their disease getting worse.

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Contacts and locations

Locations

  • Johannes Wesling Klinikum

    Minden, Germany

  • Medizinische Hochschule

    Hanover, Germany

  • Uniklinik Ulm

    Ulm, Germany

  • University Medicine Greifswald

    Greifswald, Germany

  • Universitätsklinikum Freiburg

    Freiburg im Breisgau, Germany

  • Universitätsklinikum Halle (Saale)

    Halle, Germany

  • Universitätsklinikum Schleswig-Holstein

    Lübeck, Germany

Conditions

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