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Which scan cracks the mystery of a fever that Won't quit?

NCT ID NCT07816783

Diagnosis Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Doctors struggle to find the cause of pyrexia of unknown origin, a fever of at least 38.3°C lasting three weeks or more that routine tests cannot explain. This study compares two imaging approaches as the first scan: FDG-PET/CT, which highlights tissues with unusual glucose use, and contrast-enhanced CT of the chest, abdomen, and pelvis, which shows structural changes. Researchers will enroll 132 adults with unexplained fever and track whether each scan points to a specific organ or tissue, whether that leads to a final diagnosis, how long diagnosis takes, and whether more imaging is needed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
two imaging tests: an FDG-PET/CT scan and a contrast-enhanced CT scan of the chest, abdomen, and pelvis
What this could lead to
If FDG-PET/CT proves better at pinpointing the source of unexplained fever, doctors could reach a diagnosis faster and with fewer repeat tests.
What could go wrong
This is an observational study at one center, so it can show how the two scans compare but cannot prove one causes better outcomes. Results may not apply to other hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 132 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years * irrespective of gender. * Fever ≥38.3°C documented on ≥2 occasions AND duration ≥3 weeks or inpatient fever ≥1 week without diagnosis despite routine evaluation. * Routine investigations to be done before labelling PUO: Full history \& examination, CBC, ESR/CRP, LFTs, RFTs, blood and urine cultures, urinalysis, ANA, RF, chest X-ray, abdominal ultrasound Exclusion Criteria: * Pregnancy. * Known case of immunosuppression * Contraindication or allergy to iodinated IV contrast (for CECT-CAP arm) that cannot be corrected * Prior FDG PET/CT or CECT-CAP performed prior to randomization for the current febrile illness that would preclude randomization

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Conditions

The condition(s) this trial relates to.

Fever Fever of Unknown Origin

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pyrexia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Post Graduate Institute of Medical Education and Research, Chandigarh, India

    RECRUITING

    Chandigarh, Chandigarh, 160012, India