New eye injection challenges Decades-Old laser treatment for diabetic vision threat

NCT ID NCT04278417

Completed Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study tested whether regular eye injections of a medication called brolucizumab could work as well as or better than standard laser treatment for people with proliferative diabetic retinopathy, a serious eye complication of diabetes that can cause vision loss. Nearly 700 participants were randomly assigned to receive either the injections every few months or laser treatment sessions over 96 weeks. Researchers compared how well each treatment preserved vision and controlled the progression of the eye disease.

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Contacts and locations

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Locations

Advanced Research LLC

Deerfield Beach, Florida, 33064, United States
Austin Retina Associates

Austin, Texas, 78705, United States
Blue Oc Clin Res at Palm Bch Eye Ct

Lakeland, Florida, 33801, United States
Cascade Medical Research Institute

Springfield, Oregon, 97477, United States
Charleston Neuroscience Institute

Ladson, South Carolina, 29456, United States
Cumberland Valley Retina Consultants

Hagerstown, Maryland, 21740, United States
Dean McGee Eye Institute

Oklahoma City, Oklahoma, 73104, United States
Emanuelli Research and Development Center LLC

Arecibo, 00612, Puerto Rico
Erie Retinal Surgery

Erie, Pennsylvania, 16507, United States
Eye Center of North Florida

Panama City, Florida, 32405, United States
Florida Retina Institute

Jacksonville, Florida, 32216, United States
Florida Retina Institute

Orlando, Florida, 32804, United States
Fort Lauderdale Eye Institute

Plantation, Florida, 33324, United States
John-Kenyon American Eye Institute PC

New Albany, Indiana, 47150, United States
Lundquist Inst BioMed at Harbor

Torrance, California, 90509-2910, United States
MedEye Associates

Miami, Florida, 33143, United States
Medical Center Opthamology Assoc

San Antonio, Texas, 78240, United States
Midwest Eye Institute

Indianapolis, Indiana, 46280, United States
Miramar Eye Specialists

Ventura, California, 93003, United States
National Ophthalmic Research Institute

Fort Myers, Florida, 33912-7125, United States
Novartis Investigative Site

Caba, Buenos Aires, 1116, Argentina
Novartis Investigative Site

Ciudad Autonoma de Bs As, Buenos Aires, C1015ABO, Argentina
Novartis Investigative Site

Rosario, De Santa Fe, B7602, Argentina
Novartis Investigative Site

CABA, C1061AAE, Argentina
Novartis Investigative Site

Albury, New South Wales, 2640, Australia
Novartis Investigative Site

Liverpool, New South Wales, 2170, Australia
Novartis Investigative Site

Parramatta, New South Wales, 2150, Australia
Novartis Investigative Site

Strathfield, New South Wales, 2135, Australia
Novartis Investigative Site

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Novartis Investigative Site

Blumenau, Santa Catarina, 89052-504, Brazil
Novartis Investigative Site

São Paulo, São Paulo, 01427-002, Brazil
Novartis Investigative Site

Sorocaba, São Paulo, 18031-060, Brazil
Novartis Investigative Site

Ottawa, Ontario, K2B 7E9, Canada
Novartis Investigative Site

Toronto, Ontario, M5T 2S8, Canada
Novartis Investigative Site

Boisbriand, Quebec, J7H 1S6, Canada
Novartis Investigative Site

Québec, Quebec, G1S 4L8, Canada
Novartis Investigative Site

Santiago, RM, 7560994, Chile
Novartis Investigative Site

Beijing, Beijing Municipality, 100044, China
Novartis Investigative Site

Shantou, Guangdong, 515041, China
Novartis Investigative Site

Wuhan, Hubei, 430060, China
Novartis Investigative Site

Wuhan, Hubei, 430070, China
Novartis Investigative Site

Nanjing, Jiangsu, 210000, China
Novartis Investigative Site

Nantong, Jiangsu, 226000, China
Novartis Investigative Site

Changchun, Jilin, 130041, China
Novartis Investigative Site

Shenyang, Liaoning, 110000, China
Novartis Investigative Site

Xi'an, Shaanxi, 710004, China
Novartis Investigative Site

Chengdu, Sichuan, 610041, China
Novartis Investigative Site

Tianjin, Tianjin Municipality, 300020, China
Novartis Investigative Site

Wenzhou, Zhejiang, 325027, China
Novartis Investigative Site

Beijing, 100050, China
Novartis Investigative Site

Beijing, 100191, China
Novartis Investigative Site

Beijing, 100730, China
Novartis Investigative Site

Shanghai, 200080, China
Novartis Investigative Site

Ahmedabad, Gujarat, 380 016, India
Novartis Investigative Site

Coimbatore, Tamil Nadu, 641014, India
Novartis Investigative Site

Tirunelveli, Tamil Nadu, 627003, India
Novartis Investigative Site

Chandigarh, 160012, India
Novartis Investigative Site

New Delhi, 110 029, India
Novartis Investigative Site

Nagakute, Aichi-ken, 480-1195, Japan
Novartis Investigative Site

Nagoya, Aichi-ken, 466 8560, Japan
Novartis Investigative Site

Sakura, Chiba, 285-8741, Japan
Novartis Investigative Site

Yoshida-gun, Fukui, 910-1193, Japan
Novartis Investigative Site

Kurume, Fukuoka, 830-0011, Japan
Novartis Investigative Site

Kōriyama, Fukushima, 963-8052, Japan
Novartis Investigative Site

Asahikawa, Hokkaido, 078 8510, Japan
Novartis Investigative Site

Kita-gun, Kagawa-ken, 761-0793, Japan
Novartis Investigative Site

Tsu, Mie-ken, 514-8507, Japan
Novartis Investigative Site

Matsumoto, Nagano, 390-8621, Japan
Novartis Investigative Site

Shimotsuke, Tochigi, 329-0498, Japan
Novartis Investigative Site

Chiyoda-ku, Tokyo, 101-8309, Japan
Novartis Investigative Site

Hachiōji, Tokyo, 193-0944, Japan
Novartis Investigative Site

Meguro-ku, Tokyo, 152-8902, Japan
Novartis Investigative Site

Akita, 010-8543, Japan
Novartis Investigative Site

Kobe, 650-0017, Japan
Novartis Investigative Site

Osaka, 545-8586, Japan
Novartis Investigative Site

Ciudad de, Mexico City, 06800, Mexico
Novartis Investigative Site

Mexico City, 06760, Mexico
Novartis Investigative Site

Tijuana, 22010, Mexico
Novartis Investigative Site

Makati, NCR, 1229, Philippines
Novartis Investigative Site

Makati, 1229, Philippines
Novartis Investigative Site

Pasig, 1605, Philippines
Novartis Investigative Site

Cheboksary, 428028, Russia
Novartis Investigative Site

Moscow, 119021, Russia
Novartis Investigative Site

Moscow, 127473, Russia
Novartis Investigative Site

Moscow, 127486, Russia
Novartis Investigative Site

Omsk, 644024, Russia
Novartis Investigative Site

Sterlitamak, 453128, Russia
Novartis Investigative Site

Ulyanovsk, 432063, Russia
Novartis Investigative Site

Yekaterinburg, 620109, Russia
Novartis Investigative Site

Bundang Gu, Gyeonggi-do, 13620, South Korea
Novartis Investigative Site

Seoul, Seocho Gu, 06591, South Korea
Novartis Investigative Site

Daegu, 705703, South Korea
Novartis Investigative Site

Seoul, 06351, South Korea
Novartis Investigative Site

Hualien City, 970, Taiwan
Novartis Investigative Site

Kaohsiung City, 80756, Taiwan
Novartis Investigative Site

Ankara, 06100, Turkey (Türkiye)
Novartis Investigative Site

Ankara, 06230, Turkey (Türkiye)
Novartis Investigative Site

Istanbul, 34420, Turkey (Türkiye)
Novartis Investigative Site

Izmir, 35340, Turkey (Türkiye)
Pinnacle Research Institute

Fort Lauderdale, Florida, 33309, United States
Premiere Practice Management LLC

Torrance, California, 90505, United States
Rand Eye Institute

Deerfield Beach, Florida, 33064, United States
Retina And Vitreous Of Texas

Bellaire, Texas, 77401, United States
Retina Associates

Elmhurst, Illinois, 60126, United States
Retina Associates Of Cleveland

Cleveland, Ohio, 44122, United States
Retina Associates Of South Texas PA

San Antonio, Texas, 78240, United States
Retina Associates PA

Lenexa, Kansas, 66215, United States
Retina Associates SW

Tucson, Arizona, 85704, United States
Retina Consultants TX Rsrch Ctr

Bellaire, Texas, 77401, United States
Retina Consultants of Houston PA

Houston, Texas, 77030, United States
Retina Consultants of Orange County

Fullerton, California, 92835, United States
Retina Consultants of Southern California

Redlands, California, 92374, United States
Retina- Vitreous Assoc Medical Group

Beverly Hills, California, 90211, United States
Salehi Retina Institute

Huntington Beach, California, 92647, United States
Southeastern Retina Associates P C

Knoxville, Tennessee, 37923, United States
Texan Eye P A

Austin, Texas, 78731, United States
Texas Retina Associates

Fort Worth, Texas, 76104, United States
University of Mississippi Med Ctr

Jackson, Mississippi, 39216, United States
Valley Retina Institute PA

Harlingen, Texas, 78550, United States
Virginia Eye Consultants

Norfolk, Virginia, 23502, United States

Conditions

Explore the condition pages connected to this study.

PROLIFERATIVE DIABETIC RETINOPATHY