New hope for prostate cancer: extended radioactive therapy shows promise
NCT ID NCT06531499
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing a radioactive drug called Lutetium-177 vipivotide tetraxetan in men with a specific type of advanced prostate cancer that has stopped responding to hormone therapy. The drug targets and delivers radiation directly to cancer cells. The study aims to see if giving up to 12 cycles of treatment is safe and how the radiation affects the body. About 106 men who have not had chemotherapy will participate.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Lutetium-177 vipivotide tetraxetan (a radioactive drug that targets prostate cancer cells)
What this could lead to
If successful, this could lead to a longer treatment option for men with advanced prostate cancer who have not yet had chemotherapy, potentially controlling the disease for a longer period.
What could go wrong
This is an early Phase 1 trial with only 106 participants, so safety and effectiveness are not yet proven. The radioactive treatment may cause side effects like damage to healthy organs or bone marrow suppression.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-••••
Locations
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Mayo Clinic Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nebraska Cancer Specialists
RECRUITINGOmaha, Nebraska, 68130, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Novartis Investigative Site
RECRUITINGCologne, North Rhine-Westphalia, 50937, Germany
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Novartis Investigative Site
RECRUITINGWuppertal, North Rhine-Westphalia, 42283, Germany
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Novartis Investigative Site
RECRUITINGAachen, 52074, Germany
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Novartis Investigative Site
RECRUITINGBerlin, 13353, Germany
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Novartis Investigative Site
RECRUITINGEssen, 45147, Germany
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Novartis Investigative Site
RECRUITINGMünchen, 80377, Germany
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Novartis Investigative Site
RECRUITINGRostock, 18057, Germany
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Novartis Investigative Site
RECRUITINGNijmegen, Gelderland, 6500HB, Netherlands
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Novartis Investigative Site
RECRUITINGSantiago Compostela, A Coruna, 15706, Spain
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Novartis Investigative Site
RECRUITINGMajadahonda, Madrid, 28222, Spain
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Novartis Investigative Site
RECRUITINGBarcelona, 08041, Spain
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Novartis Investigative Site
RECRUITINGBellinzona, 6500, Switzerland
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Novartis Investigative Site
RECRUITINGBern, 3010, Switzerland
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Novartis Investigative Site
RECRUITINGSutton, Surrey, SM2 5PT, United Kingdom
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Novartis Investigative Site
RECRUITINGBirmingham, West Midlands, B15 2TH, United Kingdom
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Novartis Investigative Site
RECRUITINGGlasgow, G12 0YN, United Kingdom
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Stanford University
RECRUITINGPalo Alto, California, 94304, United States
Contact
Contact Email: •••••@•••••
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University of California LA
RECRUITINGLos Angeles, California, 90095, United States
Contact
Contact Email: •••••@•••••
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Wash U School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Email: •••••@•••••
Contact