Could a standard 28-Day antibiotic course beat flexible dosing for abdominal infections?

NCT ID NCT05148702

Ongoing Disease control Sponsor: Lydia Flett Source: ClinicalTrials.gov ↗

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial compares a fixed 28-day antibiotic course against standard care (where the duration is decided by the doctor) in adults hospitalized with complicated intra-abdominal infections. About 1,100 participants will be randomly assigned to one of the two approaches and followed for 180 days. The goal is to see whether the longer fixed course reduces treatment failure and is cost-effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: antibiotics (clinician-chosen) given for a fixed 28-day course
What this could lead to: If it works, a simple rule of giving 28 days of antibiotics could reduce treatment failure and improve recovery for people with serious abdominal infections.
What could go wrong: This is a large trial, but longer antibiotic use may increase side effects, drug resistance, or costs without clear benefit over current flexible durations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Infections infectious peritonitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMPLICATED INTRA-ABDOMINAL INFECTION

Contacts and locations

Show contact details

Locations

Aneurin Bevan University Health Board

Newport, United Kingdom
Barking, Havering and Redbridge University Hospitals Nhs Trust

Romford, United Kingdom
Bolton NHS Foundation Trust

Bolton, United Kingdom
Buckinghamshire Healthcare NHS Trust

Aylesbury, United Kingdom
Chelsea and Westminster Hospital NHS Foundation Trust

London, United Kingdom
Chesterfield Royal Hospital NHS Foundation Trust

Chesterfield, United Kingdom
County Durham and Darlington NHS Foundation Trust

Darlington, United Kingdom
Cwm Taf Morgannwg University Health Board,

Abercynon, United Kingdom
East Cheshire NHS Trust

Macclesfield, United Kingdom
East Suffolk and North Essex NHS Foundation Trust

Ipswich, United Kingdom
East Sussex Hospitals NHS Trust

Saint Leonards-on-Sea, United Kingdom
Guys and St Thomas' NHS Foundation Trust

London, United Kingdom
Hull University Teaching Hospitals NHS Trust

Hull, United Kingdom
Hywel Dda University Health Board

Aberystwyth, United Kingdom
Imperial College Healthcare NHS Trust

London, United Kingdom
King'S College Hospital Nhs Foundation Trust

London, United Kingdom
Lancashire Teaching Hospitals NHS Foundation Trust

Preston, United Kingdom
Leeds Teaching Hospitals NHS Trust

Leeds, United Kingdom
Manchester University NHS Foundation Trust

Manchester, United Kingdom
NHS Grampian

Aberdeen, United Kingdom
Norfolk and Norwich University Hospitals NHS Foundation Trust

Norwich, United Kingdom
North Bristol NHS Trust

Bristol, United Kingdom
North Cumbria Integrated Care NHS Foundation Turst

Carlisle, United Kingdom
North Tees and Hartlepool NHS Foundation Trust

Stockton-on-Tees, United Kingdom
Northern Lincolnshire and Goole NHS Foundation Trust - Grimsby

Grimsby, United Kingdom
Nottingham University Hospital NHS Trust

Nottingham, United Kingdom
Royal Cornwall Hospitals NHS Trust

Truro, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield, United Kingdom
Sherwood Forest Hospitals NHS Foundation Trust

Sutton in Ashfield, United Kingdom
United Lincolnshire Hospitals NHS Trust - Pilgrim Hospital Boston

Boston, United Kingdom
University Hospital Coventry & Warwickshire

Coventry, United Kingdom
University Hospitals Plymouth NHS Trust

Plymouth, United Kingdom
University Hospitals Sussex NHS Foundation Trust

Brighton, United Kingdom
University Hospitals Sussex NHS Foundation Trust

Worthing, United Kingdom
University Hospitals of Leicester NHS Trust

Leicester, United Kingdom
UniversityHospitals Birmingham NHS Foundation Trust

Birmingham, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.