New drug combo opens for advanced GIST patients with no other options
NCT ID NCT06948955
First seen Nov 05, 2025 · Last updated May 16, 2026 · Updated 32 times
Summary
This program provides early access to an investigational drug called bezuclastinib, taken together with sunitinib, for people with advanced gastrointestinal stromal tumors (GIST) who have no other good treatment choices. The combination targets many types of KIT mutations that drive GIST. Participants must be 18 or older, able to swallow pills, and have tried or cannot tolerate imatinib.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cleveland Clinic Foundation
AVAILABLECleveland, Ohio, 44195, United States
Contact Phone: •••-•••-••••
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Dana Farber Cancer Institute (DFCI)
AVAILABLEBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-••••
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Huntsman Cancer Institute, University of Utah
AVAILABLESalt Lake City, Utah, 84112, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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MD Anderson Cancer Center
AVAILABLEHouston, Texas, 77030, United States
Contact Email: •••••@•••••
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Mayo Clinic
AVAILABLEJacksonville, Florida, 32224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic
AVAILABLERochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic Hospital
AVAILABLEPhoenix, Arizona, 85054, United States
Contact Phone: •••-•••-••••
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Memorial Sloan Kettering Cancer Center
AVAILABLENew York, New York, 10065, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Orlando Health
AVAILABLEOrlando, Florida, 32806, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shenandoah Oncology
AVAILABLEWinchester, Virginia, 22601, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Smillow Cancer Hospital - Yale New Haven Health
AVAILABLENew Haven, Connecticut, 06510, United States
Contact Email: •••••@•••••
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Taylor Cancer Research Center
AVAILABLEMaumee, Ohio, 43537, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center
AVAILABLEColumbus, Ohio, 43210, United States
Contact Email: •••••@•••••
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The University of Chicago Medical Center
AVAILABLEChicago, Illinois, 60637, United States
Contact Email: •••••@•••••
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UCLA Department of Medicine- Hematology/Oncology
AVAILABLELos Angeles, California, 90095, United States
Contact Email: •••••@•••••
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UPMC Hillman Cancer Center
AVAILABLEPittsburgh, Pennsylvania, 15232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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USC/Norris Comprehensive Cancer Center
AVAILABLELos Angeles, California, 90033, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Colorado
AVAILABLEAurora, Colorado, 80045, United States
Contact Email: •••••@•••••
Contact Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.